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Biol Trace Elem Res.
2011 Dec;144(1-3):1-5. doi: 10.1007/s12011-009-8382-1. Epub 2009 Apr 24.
Serum fluoride and sialic acid levels in
osteosarcoma.
Abstract
Osteosarcoma is a rare malignant bone
tumor most commonly occurring in children and young adults presenting with
painful swelling. Various etiological factors for osteosarcoma are ionizing
radiation, family history of bone disorders and cancer, chemicals (fluoride,
beryllium, and vinyl chloride), and viruses. Status of fluoride levels in serum
of osteosarcoma is still not clear. Recent reports have indicated that there is
a link between fluoride exposure and osteosarcoma. Glycoproteins and
glycosaminoglycans are an integral part of bone and prolonged exposure to
fluoride for long duration has been shown to cause degradation of collagen and
ground substance in bones. The present study was planned to analyze serum
fluoride, sialic acid, calcium, phosphorus, and alkaline phosphatase levels in
25 patients of osteosarcoma and age- and sex-matched subjects with bone-forming
tumours other than osteosarcoma and musculo-skeletal pain (controls, 25 each).
Fluoride levels were analyzed by ISE and sialic acid was analyzed by Warren's
method. Mean serum fluoride concentration was found to be significantly higher
in patients with osteosarcoma as compared to the other two groups. The mean
value of flouride in patients with other bone-forming tumors was approximately
50% of the group of osteosarcoma; however, it was significantly higher when
compared with patients of group I. Serum sialic acid concentration was found to
be significantly raised in patients with osteosarcoma as well as in the group
with other bone-forming tumors as compared to the group of controls. There was,
however, no significant difference in the group of patients of osteosarcoma
when compared with group of patients with other bone-forming tumors. These
results showing higher level of fluoride with osteosarcoma compared to others
suggesting a role of fluoride in the disease.
PMID:
19390788
[PubMed - indexed for MEDLINE]
PubMed Commons
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