Antimicrob Agents Chemother. 2007 Sep; 51(9): 3136–3146.
Published online 2007 Jun 18. doi: 10.1128/AAC.00372-07
PMCID: PMC2043191
PMID: 17576845
Distribution of Suramin, an Antitrypanosomal Drug, across the Blood-Brain and Blood-Cerebrospinal Fluid Interfaces in Wild-Type and P-Glycoprotein Transporter-Deficient Mice▿
This article has been cited by other articles in PMC.
Abstract
Although 60 million people are exposed to human African trypanosomiasis, drug companies have not been interested in developing new drugs due to the lack of financial reward. No new drugs will be available for several years. A clearer understanding of the distribution of existing drugs into the brains of sleeping sickness patients is needed if we are to use the treatments that are available more safely and effectively. This proposal addresses this issue by using established animal models. Using in situ brain