Why women have a higher risk of developing Alzheimer's
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I've written before about how some researchers are recommending that we
begin referring to Alzheimer's disease as type-3 diabetes because of the
role blood sugar plays in cognitive health and decline. So it shouldn't
surprise you to hear that having type-2 diabetes can increase your risk
of dementia and Alzheimer's disease. However, a new study indicates
that this risk may be different for men and women.
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Researchers believe that in general, the increased risk is likely due in
part to a decrease in the effectiveness of insulin, as this is a key
issue in both diabetes and dementia. However, scientists at the
University of Coimbra in Portugal suspected that the sex hormones may
play a role as well, particularly as women are known to be at greater
risk of developing Alzheimer's. To investigate this, they examined
changes in estrogen, insulin, oxidative stress, and markers of
Alzheimer's in male and female middle-aged rats, some of which had
type-2 diabetes and some of which served as controls.
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They found a number of differences between the male and female rats as
well as those with and without type-2 diabetes. This indicates that
treatment approaches should be different for each group. In particular,
the female rats had more cholesterol in their blood and less in their
brains. Brain function is entirely dependent on having enough
cholesterol, particularly LDL cholesterol in the brain cells.
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Continued Below...
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Additionally, low cholesterol levels in the brain can affect the ability
of the cells to respond to the female hormone estradiol. Having enough
estradiol also is important for brain function. Studies have shown that
women who restore their post-menopausal hormone levels to those typical
of premenopausal women are 60% less likely to get Alzheimer's.
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This study offers an important reminder that because changes in estrogen
levels play a significant role in brain health, women, especially
post-menopausal women, may need to be more vigilant than men about
reducing their risk factors for developing dementia. One such risk
factor is having low hormone levels. Another one is elevated blood sugar
levels that can contribute to both type-2 and "type-3" diabetes.
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Both men and women can decrease their risk of these diseases by
combining hormone restoration therapy with all of the various strategies
I mention in my book, The Type-2 Diabetes Breakthrough. It's a step by step guide to preventing, treating, and in many cases completely resolving type-2 diabetes.
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And one particularly helpful supplement for patients with type-2 diabetes is Advanced Blood Sugar Formula.
It contains powerful herbal extracts that can keep your blood sugar at a
healthy level so that you maintain normal insulin sensitivity.
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Yours for better health,
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Frank Shallenberger, MD
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Source: . |
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