Folate May Mitigate Pesticide-Related Autism by Dr. Mercola
Folate May Mitigate Pesticide-Related Autism
September 25, 2017 • 105,417views
Pesticides
appear to be a contributing factor in autism spectrum disorder (ASD). A
dysfunctional gut microbiome is suspected of being part of the problem
in ASD, and glyphosate disrupts the gut microbiome
Low
folate (vitamin B9) has also been shown to play a role in neurological
disorders. Folate is naturally produced by gut microbes, and since
glyphosate disrupts the gut microbiome, it may well lead to a decreased
ability to produce folate, thereby inducing folate deficiency
Research
shows taking the recommended 800 mcg of folic acid at the time of
conception helps lower your child’s risk of pesticide-related autism.
However, folic acid is a poor substitute for natural folate; better
alternatives are discussed
By Dr. Mercola
In the 1980s, the incidence of autism was 1 in 10,000.1,2
As of 2012 statistics from the Centers for Disease Control and
Prevention, the incidence of autism spectrum disorder (ASD) in children
between the ages of 6 and 17 was 1 in 50.3 It’s highly unlikely that the stratospheric rise in ASD could be traced back to a single culprit.
The most logical conclusion is that this wide range of brain
disorders are the result of individual responses to toxic exposures
from multiple sources, including the mother, while in utero.4 One source in particular that has been repeatedly pointed out is pesticides, and glyphosate in particular. EMF exposure is another likely candidate.5
Nearly 1 billion pounds of glyphosate are sprayed on food crops each
year in the U.S. alone (that number increases to 5 billion worldwide),
and research suggests this chemical may be a driving factor behind
many of the chronic diseases encountered in Western societies. Autism
is just one problem linked to pesticide exposure. Mothers who are
exposed to pesticides during pregnancy are also at increased risk of
premature delivery.6
Monsanto, which manufactures and sells the best-selling glyphosate-based herbicide Roundup, has maintained that Roundup and glyphosate (the active ingredient) are harmless.
But researchers such as Stephanie Seneff, Ph.D., a research
scientist at the Massachusetts Institute of Technology (MIT) and
Anthony Samsel, Ph.D., a research scientist and environmental and
public health consultant, have discovered and published papers
explaining the mechanisms by which glyphosate destroys health and
contributes to chronic disease and brain disorders such as autism.
A dysfunctional gut microbiome
has long been suspected of being part of the problem in ASD, and
glyphosate indeed disrupts the gut microbiome. The presence of certain
gut microbes in pregnant mice was again recently linked to a heightened
risk of “abnormal brain wiring” and autism-like behavior in offspring.7
In a nutshell, certain microbes trigger the release of immune-signaling
molecules that “somehow causes abnormal brain development in the
fetuses.”
Folate May Mitigate Pesticide-Induced Autism Risk
Low folate (vitamin B9, the synthetic version of which is folic
acid) has also been shown to play a role in a number of neurological
disorders. Folate is naturally produced by certain gut microbes, and
since glyphosate disrupts the gut microbiome, it may well lead to a
decreased ability to produce folate, thereby inducing folate deficiency.
Recent research by UC Davis seems to confirm this hypothesis.
They found that taking the recommended amount of folic acid at the
time of conception may in fact lower your child’s risk of
pesticide-related autism specifically. Interestingly, UC Davis is
heavily funded by the biotech industry, which has vigorously defended
itself against accusations that pesticides contribute to autism, so it’s
a pleasant surprise to see UC Davis researchers are even acknowledging
the pesticide-autism link. As reported in a UC Davis press release:8
“In the study, children whose mothers took 800 or more
micrograms [mcg] of folic acid (the amount in most prenatal vitamins)
had a significantly lower risk of developing autism spectrum disorder
(ASD) — even when their mothers were exposed to household or
agricultural pesticides associated with increased risk …
‘We found that if the mom was taking folic acid during the window
around conception, the risk associated with pesticides seemed to be
attenuated,’ said Rebecca J. Schmidt, assistant professor in the
Department of Public Health Sciences and first author on the paper.
‘Mothers should try to avoid pesticides. But if they live near
agriculture, where pesticides can blow in, this might be a way to
counter those effects.”
Women whose folic acid intake was less than 800 mcg per day and were
exposed to pesticides had “a much higher estimated risk of having a
child who developed an ASD” compared to those who took the recommended
amount and had no pesticide exposure. Not surprisingly, repeated
pesticide exposures resulted in increasingly higher risk of having a
child with ASD.
Those at greatest risk were mothers with the greatest exposure to
pesticide and the lowest folic acid intake. While this study did not
establish a causal link, Schmidt noted that:
“Folate plays a critical role in DNA methylation (a process by
which genes are turned off or on), as well as in DNA repair and
synthesis. These are all really important during periods of rapid
growth when there are lots of cells dividing, as in a developing fetus.
Adding folic acid might be helping out in a number of these genomic
functions.”
Folic Acid Supplementation May Merely Mask Toxic Exposures
While most people assume folate and folic acid are interchangeable,
it is important to realize there are significant differences between
them. Prenatal vitamins and many staple foods are fortified with folic
acid to prevent birth defects associated with deficiency during fetal development.
Being deficient in folate during the first trimester of your
pregnancy is a major risk factor for neural tube defects such as spina
bifida, anencephaly and exencephaly.
However, as noted in a Weston A. Price article by Seneff9
— in which she addresses the links between folic acid, glyphosate and
spina bifida — folate and folic acid are NOT interchangeable, even
though many researchers, who probably should know better, use them as
such. Seneff writes:
“The folic acid supplement that’s added to flour is a
synthetic version of the B vitamin, which is oxidized and missing the
methyl group. The active form of the vitamin is technically called
methyltetrahydrofolate. Folic acid is much more stable, whereas folate
easily breaks down with aging or with heat … Folic acid is a (cheaper)
synthetic molecule whereas folate is natural.
According to the U.S. government’s Code of Federal Regulations …
fortified wheat products must contain 0.7 milligrams of folic acid …
This regulation became law in 1998, at a time when genetically modified
(GM) RoundUp-Ready corn and soy crops had been on the market for a few
years … The incidence of spina bifida was also increasing at that
time, which is what alerted the government to a potential problem with
folate deficiency.
One has to wonder whether somebody involved in the introduction of
this law knew something about the potential of glyphosate to cause
spina bifida. It would not take a rocket scientist to think that
disruption of the gut microbes that naturally produce folate for the
host would lead to folate deficiency. In fact, it is a direct hit:
folate is produced from products of the shikimate pathway, and this is the pathway that even Monsanto admits is disrupted in plants and microbes by glyphosate.
Furthermore, the microbes that synthesize folate for the host,
lactobacillus and bifidobacteria, are the ones that glyphosate
preferentially kills. A continued rise in spina bifida would raise
public awareness of a hidden environmental toxicant that might be
causing this rise. Making sure that pregnant women were well supplied
with external folic acid might mask the problem.”
Folate Lowers Cancer Risk While Folic Acid May Raise it
As mentioned, folate plays a critical role in DNA methylation, but
that does not mean folic acid does as well. As noted by Seneff, while
studies confirm folate appears protective against breast and uterine
cancer, folic acid fortification of foods has been linked to an
increase in colorectal cancer since its introduction.10
Studies have also confirmed that inactive folic acid remains present
in the blood of post-menopausal women who take daily folic acid
supplements, and that natural killer cells are diminished in the
presence of elevated folic acid levels.
“What is probably happening is that the inactive folic acid is
binding to the folate receptors and preventing access by the
methyltetrahydrofolate. This gives a hint as to how excess folic acid
might increase risk to cancer: by getting in the way!” Seneff writes.
“(Methyltetrahydro) folate protects from cancer by preventing
DNA mutations, which can turn off cancer-protective genes and cause
cells to start proliferating uncontrollably. However, folate also fuels
proliferation, because it is necessary for the synthesis of certain DNA
nucleotides. Once you have a cancer growing, folate will encourage the
cancer to grow bigger.
Part of the chemotherapy program used to treat cancer involves
anti-folate drugs: drugs that interfere with folate signaling. While
these drugs prevent growth of the existing tumor, they also encourage
further DNA mutations, which could lead to metastasis from the tumor,
and it will also cause an increased risk of new cancers … Meanwhile,
anti-folate chemotherapy treatments are being widely administered to
actively reduce the bioavailability of folate, which has been shown to
fuel cancer growth, for both breast cancer and non-Hodgkin’s lymphoma.”
Why Folic Acid Supplements Are a Poor Substitute for Folate-Rich Foods
In short, while folate sufficiency helps prevent certain cancers,
excessive folic acid (the synthetic form) can encourage tumor growth,
and suppressing folate bioavailability also fuels cancer growth.
According to Seneff, there’s evidence to suggest many Americans are
getting far too much folic acid (from fortified processed foods and
supplements), and suffering ill effects from it. Meanwhile, many are
not getting enough folate from real food.
One of the reasons folic acid does not have the same effects as folate has to do with the way it’s metabolized in your body.11 Naturally-occurring folate is metabolized to tetrahydrofolate (THF) in your small intestine.
Synthetic folic acid, meanwhile, is initially reduced and methylated
in your liver, where the enzyme dihydrofolate (DHF) reductase is
required for the conversion of the folic acid into the active THF form
your body can use (THF can even cross the blood brain barrier, which
helps explain folate’s usefulness against neurological disorders).
If you have low activity of this enzyme in your liver (which many
do), and take high amounts of folic acid, you may end up with excessive
levels of unmetabolized folic acid in your system, which is what they
found in the study looking at folic acid levels in the blood of
post-menopausal women taking supplements.
Dr. Ben Lynch, a naturopathic doctor who specializes in
methylenetetrahydrofolate reductase (MTHFR) gene-related disease, also
believes folic acid is dangerous. This gene provides instructions for
making MTHFR, an enzyme that converts folic acid into methylfolate, the
active form of folate.
Mutations in this gene,12
which are quite common, results in a reduced ability to properly
process folate and folic acid, and has been linked to a decreased
ability to detoxify and a wide range of chronic health problems,
including neurological diseases, birth defects and cancers. To learn
more, please listen to Dave Asprey’s interview13 with him, in which they discuss this in greater depth.
Methylfolate — A Better Supplement Alternative
A far better alternative to folic acid is L-methylfolate (5-MTHF),
sometimes referred to as just methylfolate, which is a biologically
active form of this B vitamin.14
This form appears to be particularly beneficial if you have a MTHFR
mutation, as it circumvents the folic acid metabolism cycle.
However, when looking for a supplement containing this vitamin, you
have to be very careful, as this biologically active form has a name
that is hard to distinguish from a nonactive form of methylfolate. So,
when looking for a folate supplement, be sure to carefully read the
label, paying attention to each letter in the name:
L-methylfolate and 6(S)-methylfolate are both biologically active
forms of vitamin B9. Other names of these active forms include metafolin
and quatrefolic
D-methylfolate and 6(R)-methylfolate are biologically INACTIVE and should be avoided
Beware of supplements that list only “methylfolate” or “5-MTHF”
without specifying the exact form. Be sure it specifies containing
L-methylfolate, 6(S)-methylfolate, metafolin or quartrefolic.
More on Glyphosate and Autism
Getting back to where we started, it’s worth noting that genetically engineered (GE) crops
are far more contaminated with glyphosate than conventional crops,
courtesy of the fact that they're engineered to withstand extremely
high levels of the chemical without perishing along with the weeds.
Glyphosate contamination is a major part of the overall hazards of GE
foods, as the chemical cannot be washed off. It’s incorporated into every cell of the plant.
Former U.S. Navy staff scientist Nancy Swanson, Ph.D., has meticulously
collected statistics on glyphosate usage and various diseases and
conditions, including autism, the results of which are shown in the
graphic below. It's hard to imagine a more perfect match-up between the
rise in glyphosate usage and incidence of autism. You can access her
published articles and reports on Sustainable Pulse,15 a European website dedicated to exposing the hazards of genetically engineered foods.
Shikimate Pathway Is the Key to Understanding How Glyphosate Harms Health and Promotes ASD
Again, Monsanto insists Roundup is harmless to humans because the
mechanism of action (which allows it to kill weeds), called the
shikimate pathway, is absent in humans and animals. However, the
shikimate pathway is present in bacteria, and that’s the key to
understanding how it causes such widespread systemic harm in animals
and humans. For every cell in your body, you have about 10 microbes of
various kinds and all of them have the shikimate pathway; hence, all of
them can respond to the presence of glyphosate.
For example, the shikimate pathway produces precursors to a wide
range of neurotransmitters, including dopamine, melatonin, serotonin
and adrenaline. When you cannot produce those precursors, you become
deficient. Celiac disease is just one of many conditions that can ensue
as a result, as serotonin deficiency is strongly implicated in celiac
disease.
Research by Samsel and Seneff reveal glyphosate causes extreme
disruption of the microbe’s function and lifecycle. What’s worse,
glyphosate preferentially affects beneficial bacteria, allowing
pathogens to overgrow and take over. At that point, your body also has
to contend with the toxins produced by the pathogens. Once the chronic
inflammation sets in, you’re well on your way toward chronic and
potentially debilitating disease. This microbial disruption in the gut
is also thought to be a significant contributing factor to ASD.
Glyphosate Toxicity and ASD
Samsel and Seneff's research shows that glyphosate inhibits
cytochrome P450 (CYP) enzymes, a large and diverse group of enzymes
that catalyze the oxidation of organic substances. This, they state, is
“an overlooked component of its toxicity to mammals.”
As mentioned, toxicity of all kinds is likely a significant
contributor to ASD, and by inhibiting your body’s ability to detoxify
foreign chemical compounds, glyphosate enhances the damaging effects of
toxins and greatly elevates your risk for ASD and other neurological
disorders and chronic diseases.
Glyphosate also impairs sulfur transport, and this too plays a role
in chronic disease — everything from depression and autism to celiac
disease, heart disease and cancer. This is in part why Seneff recommends
soaking in magnesium sulfate (Epsom salt) baths rather than taking a
sulfur supplement such as chondroitin sulfate. This way, it can bypass
your gut mucosa.
The Importance of B Vitamins for Brain Health
Aside from preventing birth defects and lowering the risk of
pesticide-related ASD, getting sufficient amounts of folate (along with
other B vitamins, especially B6 and B12) is also important for the
prevention of depression and Alzheimer’s.
Here, one of the mechanisms of action is the suppression of
homocysteine, which tends to be elevated when you have brain
degeneration. If you don’t get enough of these B vitamins, your
homocysteine levels increase. Conversely, when you increase intake of
folate, B6 and B12, your homocysteine levels decrease.
One study confirming this was published in 2010.16
Participants received either a placebo or 800 mcg of folic acid, 500
mcg of B12 and 20 mg of B6. The study was based on the presumption that
by controlling homocysteine levels you might be able to reduce brain
shrinkage, thereby slowing the onset of Alzheimer’s. Indeed, after two
years those who received the vitamin regimen had significantly less
brain shrinkage compared to the placebo group.
A 2013 study17
took this research a step further, showing that B vitamins (folic acid,
B6 and B12) specifically slow shrinkage in brain regions known to be
most severely impacted by Alzheimer's. In these critical areas,
shrinkage was decreased as much as 700 percent. More generally, brain
shrinkage was reduced by up to 90 percent.
How to Increase Your Folate Intake
The best way to avoid folate (B9) deficiency is to eat plenty of
fresh, raw, organic leafy green vegetables, especially broccoli,
asparagus, spinach and turnip greens.18 Remember, for folic acid
to be of any use to you (and to be able to reach your brain through
your blood brain barrier), it must first be activated into its
biologically active form, L-5-MTHF.
Nearly half of the population has difficulty converting folic acid
into the bioactive form due to a genetic reduction in enzyme activity,
so if you take a B-vitamin supplement, make sure it contains natural or
bioavailable folate (such as nutritional yeast,19 L-methylfolate, 6(S)-methylfolate, metafolin or quartrefolic) rather than synthetic folic acid.
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