How Plumbing (Not Vaccines) Eradicated Disease
by Joel
Edwards | Guest Writer
Published
August 27, 2015 | Vaccination,
History
Before
plumbing was widely used, indoor facilities consisted of a washstand and a
washbowl, a pitcher, and a chamber pot or commode. Human waste was thrown into
the street or anywhere convenient.
Vaccines
get all the glory, but most plumbers will tell you that it was water
infrastructure—sewage systems and clean water—that eradicated disease. And
they’re right.
The History of Plumbing
After the
fall of the Roman Empire, Europeans despised all things Roman, including
bathing. There was a widespread belief that getting wet caused illness. This
contempt and fear of bathing persisted through the Dark Ages. Some
Europeans defied local customs by bathing, but this was usually done over great
protest. When Queen Elizabeth bathed, her servants panicked, fearing she would
become ill and die.
This resistance to bathing was brought across the Atlantic to America, influencing habits all the way into the 1800s. In 1835, Philadelphia almost passed an ordinance forbidding wintertime bathing. Ten years later, Boston did outlaw bathing, except by medical directive. (Though this law was not widely enforced, it does illustrate the American resistance to bathing as late as the mid 1800s.)
This resistance to bathing was brought across the Atlantic to America, influencing habits all the way into the 1800s. In 1835, Philadelphia almost passed an ordinance forbidding wintertime bathing. Ten years later, Boston did outlaw bathing, except by medical directive. (Though this law was not widely enforced, it does illustrate the American resistance to bathing as late as the mid 1800s.)
Before
plumbing was widely used, indoor facilities consisted of a washstand and a
washbowl, a pitcher, and a chamber pot or commode. Human waste was thrown into
the street or anywhere convenient.
This total lack of sanitation in urban areas filled with rats and other vermin provided the perfect environment to spread disease. The Black Plague alone killed 75 million—200 million people—including 1/3 of Europe’s population. Though this disease is not entirely eradicated, human infection has become a rare occurrence. The last plague epidemic in America was in the early 1900’s.
This total lack of sanitation in urban areas filled with rats and other vermin provided the perfect environment to spread disease. The Black Plague alone killed 75 million—200 million people—including 1/3 of Europe’s population. Though this disease is not entirely eradicated, human infection has become a rare occurrence. The last plague epidemic in America was in the early 1900’s.
Polio and Plumbing
Polio
thrives in fecal matter and is easily transmitted through human waste. Plumbing
and water sanitation in India is way behind the rest of the industrialized
world. In areas where sanitation and hygiene are good, polio is rare. In areas
where sanitation and hygiene are poor, the disease can spread rapidly.
Immunization efforts have received a lot of publicity and have garnered most of the credit for India being declared “polio free” by the World Health Organization. As recently as 2009, India reported 762 cases of polio, and at that time, these numbers made India the polio capital of the world. In 2014, there are currently no “official” documented cases of polio, but without proper sanitation there is no way this can last.
Immunization efforts have received a lot of publicity and have garnered most of the credit for India being declared “polio free” by the World Health Organization. As recently as 2009, India reported 762 cases of polio, and at that time, these numbers made India the polio capital of the world. In 2014, there are currently no “official” documented cases of polio, but without proper sanitation there is no way this can last.
A Polio Breeding Ground
India is
the second most populous nation in the world, with an estimated population of
1.2 billion. Currently, 780 million Indians do not have a toilet; 96 million
Indians do not have access to clean drinking water. In rural areas, open
defecation is still more common than attempting to dispose of human waste in a
more sanitary fashion, such as burying it.
There have been some efforts to improve sanitation, but they pale in comparison to the extensive efforts to vaccinate Indians. Over 9 billion has been spent in this vaccination public health campaign. In some parts of India, children have received as many as 30 doses of the oral polio vaccine before their fifth birthday. Bill Gates, the World Health Organization, and GAVI have ardently been pushing vaccines on people who still don’t have access to clean drinking water or the sanitary means to dispose of human waste.
There have been some efforts to improve sanitation, but they pale in comparison to the extensive efforts to vaccinate Indians. Over 9 billion has been spent in this vaccination public health campaign. In some parts of India, children have received as many as 30 doses of the oral polio vaccine before their fifth birthday. Bill Gates, the World Health Organization, and GAVI have ardently been pushing vaccines on people who still don’t have access to clean drinking water or the sanitary means to dispose of human waste.
They Say Tomato, I Say Tomatoe
The current
polio vaccine campaign in India is highly controversial due to the high rate of
vaccine injury and death. There were 53,000 cases of NPAFP, a non-polio acute
flaccid paralysis, among those vaccinated. NPAFP is a disease that is
clinically indistinguishable from polio and twice as deadly that is caused by
the live, weakened, polio viruses in the vaccine. Incidences of the disease rose
and fell with the number of doses of the vaccine administered. To call this
disease anything other than polio is semantic subterfuge, a whitewash for Big
Pharma’s image.
In the past 13 months, India has
reported 53,563 cases of NPAFP at a national rate of 12 per 100,000
children—way above the global benchmark set by WHO of 2 per 100,000.”
— January
13, 2014 quote from LiveMint Newpaper,
the second largest business newspaper in India
It would be
less expensive in human cost and far more effective to improve India’s water
infrastructure, improving India’s sanitation and hygiene.
London England and Cholera
In the
1800’s the European infant mortality rate was very high, from 25% to 70%. In
the early-to-mid 1800s, London had little in the way of water infrastructure.
The majority of people used town pumps and communal wells to get their drinking
water. Waste disposal was far from adequate. Most Londoners dumped raw sewage
and animal wastes into open pits known as “cesspools” or directly into the
Thames River. Unfortunately, the Thames River was also the source of drinking
water for many Londoners.
Cholera spreads easily through contaminated water and food and kills very quickly; it often proves fatal within hours of the first symptoms of vomiting or diarrhea.
In 1854, yet another outbreak struck London, claiming the lives of tens of thousands of Europeans. In Soho, a suburb of London, there were more than 500 fatal cases of cholera in ten days.
Dr. John Snow, who lived near Soho, was able to directly investigate what was causing the outbreak. Five years earlier, Dr. Snow had written an article about what he believed caused cholera. It was in the water, he argued. This idea flew in the face of the “wisdom” of his time. In the 1850s, doctors believed that bad vapors, or a “miasma in the atmosphere” caused disease. Dr. Snow dared to believe something different, to try something different, believing he might see different results.
Cholera spreads easily through contaminated water and food and kills very quickly; it often proves fatal within hours of the first symptoms of vomiting or diarrhea.
In 1854, yet another outbreak struck London, claiming the lives of tens of thousands of Europeans. In Soho, a suburb of London, there were more than 500 fatal cases of cholera in ten days.
Dr. John Snow, who lived near Soho, was able to directly investigate what was causing the outbreak. Five years earlier, Dr. Snow had written an article about what he believed caused cholera. It was in the water, he argued. This idea flew in the face of the “wisdom” of his time. In the 1850s, doctors believed that bad vapors, or a “miasma in the atmosphere” caused disease. Dr. Snow dared to believe something different, to try something different, believing he might see different results.
Dr. John Snow Traced Cholera to its Source
Dr. Snow
traced the cholera outbreak to the Broad Street pump. He persuaded the town
officials to remove the pump handle, and the cholera outbreak abruptly ended.
Some time later, the outbreak was traced back to a woman cleaning a dirty
diaper in the well.
Though it took some time, Dr. Snow convinced the authorities that fecal matter was contaminating the water supply. Today Dr. John Snow is widely regarded as the father of epidemiology.
Though it took some time, Dr. Snow convinced the authorities that fecal matter was contaminating the water supply. Today Dr. John Snow is widely regarded as the father of epidemiology.
Refugee Camps, Dysentery Epidemic, and Poor Sanitation
The Rwandan
refugee camps set up in Zaire in 1994 struggled with outbreaks of dysentery.
Sanitation was poor; the refugees defecated openly in common areas. Human waste
built up in the same areas where the refugees drew water that was used for
cooking and drinking. Heavy rain flooded the area and dysentery became epidemic,
at its peak it was killing 2,000 people a day.
Refugee camps have always been a haven for diseases related to poor sanitation. Once U.S. and UN officials brought in purified water and encouraged people to use outhouses and latrines for defecation, the incidences of dysentery fell.
Refugee camps have always been a haven for diseases related to poor sanitation. Once U.S. and UN officials brought in purified water and encouraged people to use outhouses and latrines for defecation, the incidences of dysentery fell.
Population Growth
The
industrial revolution drove rapid population growth. For example, Chicago’s
population grew from 350 in 1835 to more than 60,000 by 1850. Chicago’s
water infrastructure wasn’t designed to handle such a rapid rise in population.
Chicago was dealing with many different diseases, but it had especially high
rates of typhoid fever. The source of the rapid increase in disease was traced
to the city’s water and sanitation.
The majority of the city’s sewage was directed to the Chicago River, which flowed right back into Lake Michigan, which provided the city’s drinking water. This, of course, contaminated Chicago’s drinking water and created a cycle of disease.
It took many years to solve the problem, but in the early 1900s Chicago modernized their water infrastructure. They reversed the flow of several rivers and streams, and as a result, typhoid fever and all other infectious diseases plummeted.
The majority of the city’s sewage was directed to the Chicago River, which flowed right back into Lake Michigan, which provided the city’s drinking water. This, of course, contaminated Chicago’s drinking water and created a cycle of disease.
It took many years to solve the problem, but in the early 1900s Chicago modernized their water infrastructure. They reversed the flow of several rivers and streams, and as a result, typhoid fever and all other infectious diseases plummeted.
Conclusion
Sanitation
prevents disease by removing the cause of disease transmission, but this is not
new information. Moses taught sanitation. He made many rules for encampments.
The Greeks and the Romans created elaborate systems of aqueducts, baths, and
drainage. When the Roman Empire crumbled, sanitation became a lost art.
Civilization paid the price: plague after plague struck areas of dense
population.
Smallpox continued to infect Europe’s population until plumbing infrastructure became commonplace. Yet, although sanitation ended this disease, the smallpox vaccine takes the credit.
When most of us think of a conscientious objector, we think of someone who refused military service for moral or religious reasons. In the 1800s, the term came into use for someone who refused vaccinations for their children. There was a great deal of resistance to the smallpox vaccine. Some statistics placed fatalities from the vaccine as high as 1 in 200
In modern times, objections to vaccines are mounting. Refusing to vaccinate is as controversial today as it was when the first vaccines were forced on British citizens almost 200 years ago. Vaccines often contain toxins like aluminum and mercury, and many vaccines contain aborted fetal tissues. The reality of vaccine injury and death is making the news, though the propaganda and out and out lies from pharmaceutical companies cause a polarized division between those who are pro vaccine and those who are against.
If you are reading this, you probably have access to running water and a working toilet. If you choose to forego vaccines for yourself or your children, bear in mind that you will need additional protection to avoid contracting illnesses. Exercise, sleep, stress management, and a truly healthy diet are all essential for an immune system to work at optimal efficiency.
While the medical professionals and the pharmaceutical companies are quick to take credit for our increased life expectancy, in truth, they are not the heroes. Have you thanked a plumber lately?
Smallpox continued to infect Europe’s population until plumbing infrastructure became commonplace. Yet, although sanitation ended this disease, the smallpox vaccine takes the credit.
When most of us think of a conscientious objector, we think of someone who refused military service for moral or religious reasons. In the 1800s, the term came into use for someone who refused vaccinations for their children. There was a great deal of resistance to the smallpox vaccine. Some statistics placed fatalities from the vaccine as high as 1 in 200
In modern times, objections to vaccines are mounting. Refusing to vaccinate is as controversial today as it was when the first vaccines were forced on British citizens almost 200 years ago. Vaccines often contain toxins like aluminum and mercury, and many vaccines contain aborted fetal tissues. The reality of vaccine injury and death is making the news, though the propaganda and out and out lies from pharmaceutical companies cause a polarized division between those who are pro vaccine and those who are against.
If you are reading this, you probably have access to running water and a working toilet. If you choose to forego vaccines for yourself or your children, bear in mind that you will need additional protection to avoid contracting illnesses. Exercise, sleep, stress management, and a truly healthy diet are all essential for an immune system to work at optimal efficiency.
While the medical professionals and the pharmaceutical companies are quick to take credit for our increased life expectancy, in truth, they are not the heroes. Have you thanked a plumber lately?
Note: This article was reprinted
with the author’s permission. It was originally published by Organic Lifestyle Magazine. Joel
Edwards is a senior at Kennesaw State University, an anthropology major with a
broad interest in the humanities and an organic lifestyle.
References:
References:
8 Responses to How Plumbing (Not
Vaccines) Eradicated Disease
Redpill1 Reply
August 29,
2015 at 7:29 am
A Polio
Breeding Ground:
Man Sheds Vaccine-Derived Poliovirus for 28 Years
by Jeff Minerd Contributing Writer,
MedPage Today: http://www.medpagetoday.com/InfectiousDisease/GeneralInfectiousDisease/53272
Action Points
Note that this case report describes a genetically immunocompromised individual who has been shedding vaccine-derived poliovirus for more than 25 years.
Be aware that these vaccine-derived viruses are unlikely to cause infection in vaccinated individuals.
Researchers report the unusual case of an immunodeficient man who has been excreting highly virulent, vaccine-derived poliovirus for 28 years in PLOS Pathogens.
Other so-called “chronic excreters” may be out there, and they may complicate the World Health Organization’s (WHO) plans to eradicate polio, said senior investigator Javier Martin, PhD, of the U.K.’s National Institute for Biological Standards and Control in Potters Bar, and colleagues.
Chronic excreters are extremely rare. Only 73 have been identified since 1962. The man described in the study is the only one known to be excreting virus at present, and the only one to have produced vaccine-derived virus for such a long period of time, Martin and colleagues said.
However, vaccine-derived virus strains likely originating from immunodeficient individuals have been discovered in sewage samples in Slovakia, Finland, Estonia, and Israel, “indicating that an unknown number of these chronic excreters exist elsewhere,” Martin and colleagues said.
The patient is a white male from the U.K. who received a full course of childhood immunizations, including the oral polio vaccine at 5, 7, and 12 months with a booster at age 7. He was later diagnosed with common variable immunodeficiency and started on immunoglobulin therapy.
The virus isolated from the man’s stool samples is a highly antigenically drifted type 2 strain derived from the original Sabin 2 strain used in the oral vaccine. More than 90% of vaccine-derived polioviruses arise from the type 2 strain, which has not been found in the wild since 1999 and is believed to be eradicated, the scientists said.
Virus samples from the patient caused paralysis in unimmunized transgenic mice with the human poliovirus receptor. The conventional inactivated polio vaccine, based on wild poliovirus strains, protected these mice. Another vaccine, based on the Sabin oral vaccine strain, was less effective, having a variable response, the researchers reported.
Human sera from vaccinated individuals readily neutralized the most antigenically divergent strain of the vaccine-derived virus. “These results are reassuring in that they indicate that vaccinated humans are well protected against infection from these highly drifted … strains,” the scientists said.
The investigators concluded that “while maintaining high immunization coverage will likely confer protection against paralytic disease caused by these viruses, significant changes in immunization strategies might be required to effectively stop their occurrence and potential widespread transmission.”
“Eventually, new stable live-attenuated polio vaccines with no risk of reversion might be required to respond to any poliovirus isolation in the post-eradication era,” they said.
Other infectious disease experts said that monitoring for vaccine-derived viruses from immunocompromised individuals is important, but these viruses pose a minimal public health threat because they are typically unable to infect other people and circulate through a population.
Amesh Adalja, MD, of the University of Pittsburgh and spokesperson for the Infectious Disease Society of America, noted that the viruses obtained from the patient in the study were not able to recombine with other enteroviruses, which is how such viruses gain the ability to spread to and infect other people.
In addition, the mice in the study were challenged with the equivalent of 25 times the PD50 of live poliovirus, Adalja pointed out.
“That is a very high dose that doesn’t mimic a natural infection,” Adalja said. “It demonstrates the proof-of-concept that the virus could be virulent, but would a human that came into contact with the virus get what the mouse got? Probably not.”
As long as the live oral polio vaccine is used, there will be some chance of outbreaks of circulating vaccine-derived polioviruses. However, the WHO reports that after more than 10 billion doses of the live vaccine were administered around the world, only 20 instances of vaccine-derived outbreaks were identified, resulting in 758 actual cases, Adalja said.
The more important task for public health officials is to eliminate wild poliovirus from the planet, he said. “Then we can tackle circulating vaccine-derived viruses.”
The wild virus has mostly been eliminated, with some small pockets still existing in Pakistan and Afghanistan, said Cara Burns, PhD, of the CDC in Atlanta.
Public health officials are hopeful the wild virus will be completely eradicated in the next few years, though political turmoil in those countries has complicated the effort.
Vaccine-derived viruses from immunodeficient individuals “obviously could be a challenge post-eradication, but it’s a relatively minor issue,” Burns said. The occurrence is extremely rare, and vaccine-derived viruses rarely spread from the immunocompromised individual to the community, she said.
Scientists are studying the use of antiviral drugs to stop the replication of vaccine-derived virus in immunocompromised patients, Burns said.
But the key to defending against vaccine-derived viruses is immunization, because immunized individuals are protected, she said.
“We will have to keep our guard up for some time to come,” Burns said.
The study had no commercial funding. Authors reported no relevant financial interests.
Reviewed by F. Perry Wilson, MD, MSCE Assistant Professor, Section of Nephrology, Yale School of Medicine
Primary Source
PLOS Pathogens
Source Reference: Dunn G et al “Twenty-eight years of poliovirus replication in an immunodeficient individual: impact on the global polio eradication initiative” PLOS Pathogens 2015; DOI: 10.1371/journal.ppat.1005114.
Man Sheds Vaccine-Derived Poliovirus for 28 Years
by Jeff Minerd Contributing Writer,
MedPage Today: http://www.medpagetoday.com/InfectiousDisease/GeneralInfectiousDisease/53272
Action Points
Note that this case report describes a genetically immunocompromised individual who has been shedding vaccine-derived poliovirus for more than 25 years.
Be aware that these vaccine-derived viruses are unlikely to cause infection in vaccinated individuals.
Researchers report the unusual case of an immunodeficient man who has been excreting highly virulent, vaccine-derived poliovirus for 28 years in PLOS Pathogens.
Other so-called “chronic excreters” may be out there, and they may complicate the World Health Organization’s (WHO) plans to eradicate polio, said senior investigator Javier Martin, PhD, of the U.K.’s National Institute for Biological Standards and Control in Potters Bar, and colleagues.
Chronic excreters are extremely rare. Only 73 have been identified since 1962. The man described in the study is the only one known to be excreting virus at present, and the only one to have produced vaccine-derived virus for such a long period of time, Martin and colleagues said.
However, vaccine-derived virus strains likely originating from immunodeficient individuals have been discovered in sewage samples in Slovakia, Finland, Estonia, and Israel, “indicating that an unknown number of these chronic excreters exist elsewhere,” Martin and colleagues said.
The patient is a white male from the U.K. who received a full course of childhood immunizations, including the oral polio vaccine at 5, 7, and 12 months with a booster at age 7. He was later diagnosed with common variable immunodeficiency and started on immunoglobulin therapy.
The virus isolated from the man’s stool samples is a highly antigenically drifted type 2 strain derived from the original Sabin 2 strain used in the oral vaccine. More than 90% of vaccine-derived polioviruses arise from the type 2 strain, which has not been found in the wild since 1999 and is believed to be eradicated, the scientists said.
Virus samples from the patient caused paralysis in unimmunized transgenic mice with the human poliovirus receptor. The conventional inactivated polio vaccine, based on wild poliovirus strains, protected these mice. Another vaccine, based on the Sabin oral vaccine strain, was less effective, having a variable response, the researchers reported.
Human sera from vaccinated individuals readily neutralized the most antigenically divergent strain of the vaccine-derived virus. “These results are reassuring in that they indicate that vaccinated humans are well protected against infection from these highly drifted … strains,” the scientists said.
The investigators concluded that “while maintaining high immunization coverage will likely confer protection against paralytic disease caused by these viruses, significant changes in immunization strategies might be required to effectively stop their occurrence and potential widespread transmission.”
“Eventually, new stable live-attenuated polio vaccines with no risk of reversion might be required to respond to any poliovirus isolation in the post-eradication era,” they said.
Other infectious disease experts said that monitoring for vaccine-derived viruses from immunocompromised individuals is important, but these viruses pose a minimal public health threat because they are typically unable to infect other people and circulate through a population.
Amesh Adalja, MD, of the University of Pittsburgh and spokesperson for the Infectious Disease Society of America, noted that the viruses obtained from the patient in the study were not able to recombine with other enteroviruses, which is how such viruses gain the ability to spread to and infect other people.
In addition, the mice in the study were challenged with the equivalent of 25 times the PD50 of live poliovirus, Adalja pointed out.
“That is a very high dose that doesn’t mimic a natural infection,” Adalja said. “It demonstrates the proof-of-concept that the virus could be virulent, but would a human that came into contact with the virus get what the mouse got? Probably not.”
As long as the live oral polio vaccine is used, there will be some chance of outbreaks of circulating vaccine-derived polioviruses. However, the WHO reports that after more than 10 billion doses of the live vaccine were administered around the world, only 20 instances of vaccine-derived outbreaks were identified, resulting in 758 actual cases, Adalja said.
The more important task for public health officials is to eliminate wild poliovirus from the planet, he said. “Then we can tackle circulating vaccine-derived viruses.”
The wild virus has mostly been eliminated, with some small pockets still existing in Pakistan and Afghanistan, said Cara Burns, PhD, of the CDC in Atlanta.
Public health officials are hopeful the wild virus will be completely eradicated in the next few years, though political turmoil in those countries has complicated the effort.
Vaccine-derived viruses from immunodeficient individuals “obviously could be a challenge post-eradication, but it’s a relatively minor issue,” Burns said. The occurrence is extremely rare, and vaccine-derived viruses rarely spread from the immunocompromised individual to the community, she said.
Scientists are studying the use of antiviral drugs to stop the replication of vaccine-derived virus in immunocompromised patients, Burns said.
But the key to defending against vaccine-derived viruses is immunization, because immunized individuals are protected, she said.
“We will have to keep our guard up for some time to come,” Burns said.
The study had no commercial funding. Authors reported no relevant financial interests.
Reviewed by F. Perry Wilson, MD, MSCE Assistant Professor, Section of Nephrology, Yale School of Medicine
Primary Source
PLOS Pathogens
Source Reference: Dunn G et al “Twenty-eight years of poliovirus replication in an immunodeficient individual: impact on the global polio eradication initiative” PLOS Pathogens 2015; DOI: 10.1371/journal.ppat.1005114.
No comments:
Post a Comment