Study Finds Aluminum in Vaccines May Raise Asthma Risks
A new federally funded study has found a possible association between aluminum-containing inactivated vaccines injected into children under age two and the risk of developing asthma before age five. Researchers are urging caution in interpretation of the results of the retrospective observational study and say more research is needed to confirm the findings.1
Researchers gathered data from 327,000 children in the United States born between 2008 and 2014. They looked at whether the children were given aluminum containing vaccines before age two and whether they developed “persistent asthma” between ages two to five. The study suggested those who were vaccinated before age two had at least a 36 percent higher risk of an asthma diagnosis than those who had fewer aluminum containing vaccines before age two.2
The researchers also found that for each milligram of aluminum received through vaccines, the risks of asthma rose 26 percent in children with existing eczema—often an early indicator of asthma—and the asthma risk rose 19 percent in kids who did not have a history of eczema.
The study was funded by the Centers for Disease Control and Prevention (CDC) and published in the medical journal Academic Pediatrics. The CDC has stated that it will not alter its recommendations based on this single study and that this is the first study that has found a link between asthma and childhood vaccines.
2005 Study Found a Potential Link Between Vaccination and Asthma, Hay Fever and Eczema
However, the National Vaccine Information Center (NVIC) worked with University of Chicago asthma researchers more than 15 year ago to investigate a potential link between childhood vaccines and atopic disease (asthma, hay fever or eczema) using an IRB-approved cross-sectional survey. The results of that study were published in Journal of Allergy and Clinical Immunology in 2005 and the conclusion was that “parents who refuse vaccination reported less asthma and allergies in their unvaccinated children.” The researchers said:
The data included 515 never vaccinated, 423 partially vaccinated, and 239 completely vaccinated children. In multiple regression analyses there were significant (P < .0005) and dose-dependent negative relationships between vaccination refusal and self-reported asthma or hay fever only in children with no family history of the condition and, for asthma, in children with no exposure to antibiotics during infancy. Vaccination refusal was also significantly (P < .005) and negatively associated with self-reported eczema and current wheeze. A sensitivity analysis indicated that substantial biases would be required to overturn the observed associations.
Aluminum Adjuvants in Vaccines Since 1930s
Aluminum has been present in some vaccines since the 1930s. Vaccine manufacturers add aluminum to inactivated injectable vaccines as an adjuvant to provoke a stronger inflammatory immune response in an effort to make the vaccines more effective. According to the CDC schedule, a two-year-old child is given multiple doses of 15 different vaccines, with seven of those vaccines containing aluminum. In 2013, the Institute of Medicine (now the National Academy of Medicine) called for more research to evaluate the safety of the early childhood vaccine schedule.2 3
Other Aluminum Exposures Linked to Asthma
According to STAT News, the CDC, the Food and Drug Administration (FDA) and the National Institutes of Health (NIH) are in further discussions about what additional studies could be conducted to evaluate the potential association between aluminum containing vaccines and asthma.1
Scientists noted an increase in childhood allergies and asthma among children in the U.S. beginning in the 1980s. Previous studies conducted or funded by public health officials failed to find a link between aluminum-containing vaccines and allergies or asthma.
However, other studies have been published reporting a link between exposure to aluminum in industrial workplaces and asthma. Additional studies have shown that mice injected with aluminum demonstrate immune responses that cause the same airway inflammation seen in childhood asthma.4 Additional studies have shown that mice injected with aluminum demonstrate immune responses that cause the same airway inflammation seen in childhood asthma.
Matthew Daly, MD, the recent study’s lead author said that the CDC funded study was done in response to a 2013 report published by the Institute of Medicine, which called for more research into the safety of the CDC recommended childhood vaccine schedule for children from birth to age six. Current and former CDC staff members were part of Dr. Daly’s research team.2
The study authors tried to account for factors that would alter results finding an association between aluminum containing childhood vaccines and asthma, such as race and ethnicity, children who were born prematurely, or children with food allergies. Some factors they were unable to address or account for included if children were exposed to aluminum from other sources, such as aluminum found in food or other environmental exposures.
While some doctors defending the safety of childhood vaccines criticized the study, others say the researchers pulled information “from a respected set of patient data and worked carefully with the best information that was available.”2
Michael Osterholm, PhD, MPH, director of the University of Minnesota’s Center for Infectious Disease Research and Policy, called the study “public health at its best,” stating “it’s our job to exhaustively examine that to see if that’s true.” Dr. Daley said that if the link were found between asthma and aluminum-containing vaccines, it is possible it could prompt a redesign of childhood vaccines.2
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