A
40-year-old previously unpublished trial shows that while replacing
saturated fat with vegetable oil lowered total cholesterol by 14
percent, for every 30 point drop in total cholesterol there was a 22
percent increased chance of death
Many
other trials have also found that replacing saturated fats with
vegetable oils increase mortality risk from all causes, including
coronary heart disease and cardiovascular disease
Processed
vegetable oils contribute to devastating attacks to your health and
attacks your brain in several ways, thereby contributing to and
worsening neurologic disorders
By Dr. Mercola
For the past four decades, the U.S. government has warned that eating
cholesterol-rich foods such as eggs would raise your LDL cholesterol
(inappropriately referred to as "bad" cholesterol) and promote heart
disease.
Alas, decades' worth of research utterly failed to demonstrate this
correlation, and the 2015-2020 Dietary Guidelines for Americans1,2,3,4,5
finally addressed this scientific shortcoming, announcing "cholesterol
is not considered a nutrient of concern for overconsumption."6
This is good news, since dietary cholesterol plays an important role in
brain health and memory formation, and is indispensable for the building
of cells and the production of stress and sex hormones, as well as
vitamin D. (When sunlight strikes your bare skin, the cholesterol in
your skin is converted into vitamin D.)
Unfortunately, the dietary guidelines still cling to outdated misinformation about saturated fat, wrongly accusing it of raising LDL and contributing to heart disease.
Here, science has shown that saturated fat only raises the safe, fluffy
LDL particles. It also increases HDL, which is beneficial for your
heart.
The guidelines became and are still confusing because the basic
premise was wrong. Dietary fat is indeed associated with heart disease,
but it's the processed vegetable oils, which are loaded with trans fats
and oxidized omega-6 fats, that are the problem, not saturated fats.
The introduction of industrialized, highly processed and frequently
heated omega-6 vegetable oils distorted the vitally important omega
6-to-3 ratio, causing metabolic catastrophes. The problem was further
exacerbated by replacing saturated fat with refined carbohydrates, which
were incorrectly viewed as a healthier option, thanks to misinformation
created and spread by the sugar industry.
Impairs Electrical Storage Potential of Your Cells
Nutrition and biochemistry are clearly important to your health, but so
is your body's electrical system. All our membranes are made of fats
that are insulators and connected through a conductor. This arrangement
sets up a biological capacitor to store electrons — but only if the fats
are healthy.
If you consume damaged fats, or worse, heated and hydrogenated oils,
the fatty acids in the cell membrane essentially become nonfunctional
and unable to store body voltage, thus increasing the risk for disease.
This is one of many reasons why it is so vital to eat healthy fats.
Unpublished Research Undermines Decades of Dietary Advice
Ancel Keys was one of the most prominent nutritional researchers of
the mid-20th century. He gained enormous professional and influential
prominence and his views were widely adopted by professional and public
health organizations. His research formed the foundation for all of the
low-fat recommendations that followed. Interestingly, some of his own
follow-up research actually undermined his hypotheses on cholesterol and
saturated fat, but these findings were never published.
Had they been, the cholesterol and low-fat myths might never have
gained the same kind of traction. The four decades' old study in
question was unearthed by Dr. Christopher E. Ramsden, who specializes in
digging up and reevaluating lost studies that challenge mainstream
health advice.7,8,9,10,11,12,13,14,15,16
Keys, who was largely funded by the sugar industry, is believed to
have been responsible for suppressing this damning study, as it doesn't
support his original hypothesis. Only parts of the trial's results were
ever published, leaving out the controversial finding that replacing
saturated fats with vegetable oil had no benefit on mortality. As
reported by Scientific American:17
"Ramsden, of the National Institutes of Health, unearthed raw
data from a 40-year-old study, which challenges the dogma that eating
vegetable fats instead of animal fats is good for the heart. The study,
the largest gold-standard experiment testing that idea, found the
opposite …
Although the study is more than just another entry in the
long-running nutrition wars — it is more rigorous than the vast majority
of research on the topic — Ramsden makes no claims that it settles the
question. Instead, he said, his discovery and analysis of long-lost
data underline how the failure to publish the results of clinical trials
can undermine truth."
Saturated Fat Vindicated in Largest Most Rigorous Trial of Its Kind
The study,18
conducted from 1968 to 1973, included 9,423 participants between the
ages of 20 and 97, making it the largest trial of its kind. The
participants were also residents of state mental hospitals and a nursing
home, making it one of the most rigorously detailed studies as the
meals of every person were carefully logged.
On the average, each patient was followed for about 15 months.
Participants were randomly assigned to one of two groups, receiving
either:
A then-standard diet containing 18.5 percent saturated fat from
animal fats such as milk, cheese, beef and shortening, and 5 percent
unsaturated fat, based on total calories
A diet in which 50 percent of the saturated fats
were replaced with vegetable oil (a mainstay in today's processed
foods) and corn oil margarine (total 9 percent saturated fat and 13
percent unsaturated fat)
After analyzing the data, Ramsden and his team found that vegetable
oils lowered total cholesterol levels by an average of 14 percent after
one year. However, this lower cholesterol did not result in improved
health and longevity, which is the conventional belief. Instead, the
research showed that the lower the cholesterol, the higher the risk of
dying!
For every 30 point drop in total cholesterol there was a 22 percent
increased chance of death. In the 65 and older category, those who
received vegetable oil experienced roughly 15 percent more deaths
compared to seniors in the saturated fat group.
The vegetable oil also did not result in fewer cases of atherosclerosis or heart attacks.
On the contrary, autopsies revealed both groups had similar levels of
arterial plaque, but 41 percent of the vegetable oil group showed signs
of at least one heart attack compared to just 22 percent of those in
the saturated fat group.
According to the authors:
"Available evidence from randomized controlled trials shows that
replacement of saturated fat in the diet with linoleic acid [vegetable
oil] effectively lowers serum cholesterol but does not support the
hypothesis that this translates to a lower risk of death from coronary
heart disease or all causes."
Why Vegetable Oils Are so Bad for Your Health
Later this year I will post my interview with Dr. Cate Shanahan, author
of "Deep Nutrition: Why Your Genes Need Traditional Food,"19
in which she delves into the profound harms done by processed vegetable
oils in the modern diet. To learn more, keep your eyes open for that
interview.
According to Shanahan, vegetable oil is your brain's worst enemy,
attacking it "at seven distinct vulnerability points using seven
distinct strategies. All seven strategies are at work in causing autism
and other childhood neurologic disorders." This includes:
Promoting gut inflammation and leaky gut.
This inflammation often causes heartburn, which can serve as a red
flag. Unfortunately, many misattribute heartburn to spicy foods rather
than the more significant culprit, namely vegetable oils
Disrupting the regulation of blood flow through the arteries in your brain and depleting your brain of antioxidants
Turning your immune system against you by affecting your white blood
cells (immune system cells), causing disease and nerve degenerating
reactions
Attacking the nerve cellular architecture. "Vegetable oils cause an
overload of oxidative reactions inside the cell, leading to the
accumulation of intracellular trash. When this affects our white matter,
we lose our mobility. When it affects our gray matter, we lose our
personalities and our connections to the world," Shanahan explains in
her book20
Impairing brain development through mutagenic effects on DNA and altered epigenetic expression
Other reasons why vegetable oils cause heart disease and other health problems include the following:
Omega-6 polyunsaturated fats,
when taken in large amounts, cannot be burned for fuel. Instead,
they're incorporated into your cellular and mitochondrial membranes,
where they are highly susceptible to oxidative damage. As a result, your
metabolic machinery is damaged. Vegetable oils made from genetically
engineered (GE) crops (as most are) have additional health risks, as
they tend to be loaded with toxic herbicide residues like Roundup.
While your body needs some omega-6, most get far too much of it
compared to omega-3, and this lopsided ratio can also have adverse
health consequences.
When heated, vegetable oils tend to oxidize. According to Dr. Fred Kummerow,21 who has researched lipids and heart disease for eight decades, oxidized cholesterol
is the real culprit that causes heart disease. By triggering
inflammation, it promotes the clogging of arteries and associated
cardiovascular problems, including heart attacks.
Many Studies Have Debunked the Saturated Fat Myth
Several other studies have also demonstrated that replacing saturated
fats with vegetable oils is a bad idea. While the benefits for
cardiovascular mortality and risk-factor reduction have been mixed, none
of these trials showed that restricting saturated fats reduced total
mortality:
Recovered data from the Sydney Diet Heart Study:
In 2013, Ramsden's team analyzed four trials looking at the effects of
replacing saturated fats with vegetable oils. Replacing saturated fats
with linoleic acid-rich vegetable oils increased mortality risk from all
causes, including coronary heart disease and cardiovascular disease22
The Oslo Study (1968): A study of 412 men,
aged 30-64 years, found eating a diet low in saturated fats and high in
polyunsaturated fats had no influence on rates of sudden death23
L.A. Veterans Study (1969): A study of 850
elderly men that lasted for six years is widely used to support the
diet-heart hypothesis. No significant difference was found in rates of
sudden death or heart attack among men eating a mostly animal-foods diet
and those eating a high-vegetable oil diet. However, more non-cardiac
deaths, including from cancer, were seen in the vegetable oil group24
London Soybean Oil Trial (1968): This study
of nearly 400 men that lasted for two to seven years found no difference
in heart attack rate between men following a diet low in saturated fats
and high in soybean oil and those following an ordinary diet25
The U.S. Multiple Risk Factor Intervention Trial (MRFIT):
Sponsored by the National Heart, Lung and Blood Institute, this is
another study that is highly misleading. It compared mortality rates and
eating habits of over 12,000 men, and the finding that was widely
publicized was that people who ate a low saturated fat and
low-cholesterol diet had a marginal reduction in coronary heart disease.
However, their mortality from all causes was actually higher26
A 2013 editorial published in the BMJ
described how the avoidance of saturated fat actually promotes poor
health in a number of ways. As stated by the author, Dr. Aseem Malhotra,
an interventional cardiology specialist registrar at Croydon University
Hospital in London:27
"The mantra that saturated fat must be removed to reduce the
risk of cardiovascular disease has dominated dietary advice and
guidelines for almost four decades. Yet scientific evidence shows that
this advice has, paradoxically, increased our cardiovascular risk ... The aspect of dietary saturated fat that is believed to have the
greatest influence on cardiovascular risk is elevated concentrations of
low density lipoprotein (LDL) cholesterol. Yet the reduction in LDL
cholesterol from reducing saturated fat intake seems to be specific to
large, buoyant (type A) LDL particles, when in fact it is the small,
dense (type B) particles (responsive to carbohydrate intake) that are
implicated in cardiovascular disease. Indeed, recent prospective cohort studies have not supported any
significant association between saturated fat intake and cardiovascular
risk. Instead, saturated fat has been found to be protective."
A 2014 meta-analysis
published in the Annals of Internal Medicine (which included data from
76 studies and more than a half-million people) found that those who
consume higher amounts of saturated fat have no more heart disease than
those who consume less. Moreover, those who ate higher amounts of
unsaturated fat, including both (healthy) olive oil and (unhealthy) corn
oil — both of which are recommended over saturated fats — did not have
lower incidence of heart disease28
A 2015 meta-analysis published in the BMJ
also failed to find an association between high levels of saturated fat
in the diet and heart disease. Nor did they find an association between
saturated fat consumption and other life-threatening diseases like
stroke or type 2 diabetes29
In summary, industrially processed, highly refined vegetable oils do
not reduce your risk of dying from heart disease. Put another way,
saturated fats do not increase your risk of dying from heart disease
either. Moreover, reducing cholesterol is not necessarily a sign of
improved health; it may actually increase your risk of death. As noted
by Ramsden:30
"One would expect that the more you lowered cholesterol, the
better the outcome. But in this case the opposite association was found.
The greater degree of cholesterol-lowering was associated with a
higher, rather than a lower, risk of death."
Statins Revisited
The cholesterol myth has been a boon to the pharmaceutical industry, as
cholesterol-lowering statins — often prescribed as a primary prevention
against heart attack and stroke related to high cholesterol — have
become one of the most frequently used drugs on the market. In 2012,
nearly 28 percent of American adults over the age of 40 reported using a
statin.31
Updated cholesterol treatment guidelines
issued by the American College of Cardiology and the American Heart
Association (AHA) in 2013 made another 9.3 million Americans eligible
candidates for the drug. However, researchers have repeatedly warned the
cardiovascular risk calculator32 used may be overestimating your risk by anywhere from 75 to 150 percent.33 This means even healthy people at low risk for heart problems are being turned to statins.
What's worse, the guideline also removed the recommendation to use the
lowest drug dose possible. Instead, the sole focus is on statin-only
treatment at higher dosages. The guidelines also ignore the density of
the lipoproteins (the LDL and HDL). Large fluffy LDL particles are not
harmful. Only small dense LDL particles can potentially cause problems
as they can squeeze through the lining of your arteries. If they
oxidize, they can cause damage and inflammation.
This means you could potentially have an LDL level of 190 but still be
at low risk as long as your LDLs are large, and your HDL-to-total
cholesterol ratio is above 24 percent. As mentioned earlier, saturated
fat not only increases your HDL, it also increases large, fluffy LDLs,
which is what you want.
Two Leading Cholesterol Guidelines Differ in Their Recommendations
Now, researchers have revisited the cholesterol guidelines, noting there
are significant differences between the two leading guidelines in the
U.S.34
In 2016, the U.S. Preventive Services Task Force (USPSTF) released its
own cholesterol treatment guidelines, which suggests statins should not
be used unless the patient has at least one other risk factor (such as
high blood pressure, diabetes or smoking) in addition to having a 10
percent risk on the cardiovascular risk calculator.
Under these guidelines, an estimated 17.1 million Americans are
candidates for a statin, compared to the 26.4 million covered by the
American College of Cardiology/AHA guidelines. The differences between
the two guidelines have caused a great deal of debate among experts.
Which one's better? As Michael Pencina, a professor of biostatistics
and bioinformatics at the Duke Clinical Research Institute and lead
author of the study told CNN:35 "There's generally confusion on who should be getting statins. I don't think we have the perfect guideline yet."
In my view, the number needed to treat offers compelling clues to the
overall uselessness of statins. According to an analysis by the USPSTF,
published last year:36
100 people need to take a statin as a primary preventive for five
years in order for one or two people to avoid a heart attack, and none
will actually live longer
250 people need to take a statin for up to six years in order to prevent a single death from any cause
A 2015 report37
published in the Expert Review of Clinical Pharmacology concluded that
"statistical deception created the appearance that statins are safe and
effective in primary and secondary prevention of cardiovascular
disease."
By using relative risk reduction, the trivial benefits of statins are
amplified. If you look at absolute risk, statin drugs benefit a mere 1
percent of the population. As noted by the USPSTF, this report found
that out of 100 people treated with the drugs, one person will have one
less heart attack.
Statins Do Not Reduce Mortality, and Can Seriously Harm Your Health
Other studies38
have also found that statins provide no reduction in mortality when
used preventatively — even in at-risk groups. This strongly suggests
statins have even less of a benefit among those already at low risk of
heart disease. Recent research39
has also confirmed that high cholesterol is not linked with heart
disease in the elderly, prompting the researchers to conclude that
reducing cholesterol levels with statin drugs is "a waste of time."
Indeed, Stephanie Seneff, Ph.D. and senior scientist at MIT, believes heart disease is a cholesterol deficiency
problem, which is essentially the converse of the conventional
paradigm. Still, her hypothesis appears to be supported by studies
showing people with higher levels of cholesterol actually live longer
than those with lower levels.
Aside from being a "waste of time" and not doing anything to reduce
mortality, statins also carry with them a list of over 200 side effects
and clinical challenges, including:40,41
Increased risk of diabetes (there are several mechanisms for this, including increasing insulin resistance and raising your blood sugar)
Acute liver disease
Muscle pain, tenderness or weakness
Rhabdomyolysis (a condition involving the death of muscle fibers),
Acute kidney failure
Chronic liver dysfunction
Reduced ketone production.42 Ketones are water-soluble fat nutrients important for tissue health.
They're also important molecular signaling molecules
Depletes
your body of essential vitamins, minerals and nutrients, including
CoQ10 and vitamin K2, both of which are important for cardiovascular and
heart health
Impaired fertility and reduced sex drive.
Importantly, statins are a Category X medication, meaning they cause
serious birth defects, so they should NEVER be used by a pregnant woman
or women planning a pregnancy
Increased risk of cancer. Long-term statin use (10 years or
longer) more than doubles women's risk of two major types of breast
cancer: invasive ductal carcinoma and invasive lobular carcinoma43
Nerve damage. Research has shown statin treatment lasting longer than two years causes "definite damage to peripheral nerves"44
Making Sense of Your Cholesterol Levels and Assessing Your Heart Disease Risk
Embed this infographic on your website:
Click on the code area and press CTRL + C (for Windows) / CMD + C (for Macintosh) to copy the code
As a general rule, cholesterol-lowering drugs are not required or
prudent for the majority of people — especially if both high cholesterol
and longevity run in your family. Also keep in mind that your overall
cholesterol level says very little about your risk for heart disease.
For more information about cholesterol and what the different levels
mean, take a look at the infographic above. As for evaluating your heart
disease risk, the following tests will provide you with a far more
accurate picture than your total cholesterol or LDL level alone:
HDL/Cholesterol ratio
HDL
percentage is a very potent heart disease risk factor. Just divide your
HDL level by your total cholesterol. That percentage should ideally be
above 24 percent
Triglyceride/HDL ratio
You can also do the same thing with your triglycerides and HDL ratio. That percentage should be below 2
Large
LDL particles are not harmful. Only small dense LDL particles can
potentially be a problem, as they can squeeze through the lining of your
arteries. If they oxidize, they can cause damage and inflammation.
Some groups, such as the National Lipid Association, are now
starting to shift the focus toward LDL particle number instead of total
and LDL cholesterol, in order to better assess your heart disease risk.
Once you know your particle size numbers, you and your doctor can develop a more customized program to help manage your risk
Your fasting insulin level
Any meal or snack high in carbohydrates like fructose and refined
grains generates a rapid rise in blood glucose and then insulin to
compensate for the rise in blood sugar.
The insulin released from eating too many carbs promotes fat
accumulation and makes it more difficult for your body to shed excess
weight. Excess fat, particularly around your belly, is one of the major
contributors to heart disease
Your fasting blood sugar level
Studies
have shown that people with a fasting blood sugar level of 100-125
mg/dl had a nearly 300 percent increased higher risk of having coronary
heart disease than people with a level below 79 mg/dl
Your iron level
Iron
can be a very potent oxidative stress, so if you have excess iron
levels you can damage your blood vessels and increase your risk of heart
disease. Ideally, you should monitor your ferritin levels and make sure
they are not much above 80 ng/ml.
The simplest way to lower them if they are elevated is to donate your
blood. If that is not possible you can have a therapeutic phlebotomy
and that will effectively eliminate the excess iron from your body
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