Social Anxiety Disorder Linked to High Serotonin Levels, Throwing Treatment with SSRIs into Serious Question
By Dr. Mercola
Depression and other mental health problems are at epidemic levels judging by the number of antidepressants prescribed each year.
According to CDC data,1
one in 20 Americans over the age of 12 report some form of depression,
and 11 percent of the US population over the age of 12 is on
antidepressant medication.2
This despite overwhelming evidence showing that antidepressants do not work as advertised.
At best, antidepressants are comparable to placebos. At worst they can
cause devastating side effects, including deterioration into more
serious mental illness, and suicidal or homicidal tendencies.
Virtually all of the school and mass shooters, for example, have been on
antidepressants. Antidepressants are also prescribed to pregnant women,
which can have serious repercussions for the child.
Research3
shows boys with autism are three times more likely to have been exposed
to antidepressants known as selective serotonin reuptake inhibitors
(SSRIs) in utero than non-autistic boys. Those whose mothers used SSRIs
during the first trimester were found to be at greatest risk.
Recent research into the mechanisms driving anxiety and social phobias
now turn conventional drug treatment with SSRIs on its ear.
Turns out these mental health problems are not due to low serotonin levels as previously thought. They're linked to high levels! If these findings are taken as seriously as they should be, the mental health field is in for a major overhaul.
The Low Serotonin Theory Was Never Proven True, Yet Spawned a Booming Market of SSRIs
Prozac was released in 1987 in the US, giving rise to an entire new
antidepressant therapy class known as selective serotonin reuptake
inhibitors (SSRIs). Some of the most popular ones include:
- Prozac (fluoxetine)
- Celexa (citalopram)
- Zoloft (sertraline)
- Paxil (paroxetine)
- Lexapro (escitalopram)
SSRIs work by preventing the reuptake (movement back into the nerve
endings) of the neurotransmitter serotonin. This makes more serotonin
available for use in your brain, which is thought to improve your mood.
Most people have heard of the "chemical imbalance" theory, which states that depression
and anxiety disorders are due to low serotonin levels. Most believe
this theory to be true. But the theory was just that—a theory. It sounds scientific, but there was actually no hard evidence behind it.
As explained by investigative health journalist Robert Whitaker,
in 1983 the National Institutes of Mental Health (NIMH) investigated
whether or not depressed individuals had low serotonin. At that time,
they concluded there was no evidence that there is anything wrong in the
serotonergic system of depressed patients.
Research 4, 5
published in 2009 added further evidence to the pile indicating the low
serotonin idea was incorrect, as they found strong indications that
depression actually begins further up in the chain of events in the
brain. Essentially, the medications have been focusing on the effect,
not the cause.
Drug companies kept running with the low serotonin theory though, as it
justifies the aggressive use of antidepressants to correct this alleged
"imbalance." Now, Swedish research really throws the justification for using SSRIs to treat anxiety disorders into question.
Anxiety Linked to High Serotonin Levels, Making SSRIs a Questionable Remedy
More than 25 million Americans report suffering from social anxiety
disorder, which makes them feel embarrassed or severely uncomfortable in
public situations.
As with depression, low serotonin has been the prevailing theory for
explaining social anxiety, and hence SSRIs are typically prescribed for
this disorder. (Other commonly prescribed anti-anxiety drugs include benzodiazepines, such as Ativan, Xanax, and Valium.
These are also associated with serious risks, including memory loss,
hip fractures, and addiction. Among women who take SSRI's to counter
symptoms of menopause, the drugs can significantly elevate their risk
of bone fractures, and this risk lingers for several years.
One recent study6
found that, compared to women treated with H2 antagonists or proton
pump inhibitors (indigestion drugs), SSRI's raised bone fracture rates
by 76 percent in one year.
After two years of treatment, the
fracture rate was 73 percent higher.People who take these drugs are also
nearly four times more likely to die prematurely than people who
don't, and also have a 35 percent greater risk of cancer.)
As reported by Medical Daily:7
[Dr. Tomas] Furmark and Dr. Mats Fredrikson, another professor of
psychology at Uppsala University, questioned the underlying hypothesis
of treating patients with SSRIs: What molecular role, exactly, does
serotonin play in social phobia?8,9,10,11
To discover the truth, they used brain scanning technology, PET
scans, to measure serotonin in the brains of volunteers with social
phobia...
Communication within the brain works like this: Nerve cells release
serotonin into the space between nerve cells. Then, serotonin attaches
itself to receptor cells. Following this, serotonin is released from the
receptor and returns to the original cell.
The researchers discovered patients with social phobia were
producing too much serotonin in the amygdala. This brain region, tucked
deep inside our skulls, is the seat of our most primitive emotions,
including fear. The more serotonin produced in this area, then, the more
anxious people feel in social situations."
Previous studies have revealed that increased nerve activity in the
amygdala is part of the underlying mechanism that produces anxiety.
Basically, those with social phobia have an over-active fear center.
These new findings provide additional information, suggesting increased
serotonin production in the brain may be part of this mechanism.
Either way, when it comes to treating this anxiety disorder, increasing
serotonin in your brain with an SSRI will not soothe your anxiety. It
will increase it, making SSRIs a questionable treatment option.
Fermented Foods May Help Social Anxiety Disorder, Study Finds
The impact of your gut microbiome on your brain function
has been confirmed by a number of studies, and research is moving
rather swiftly in this area. One of the reasons for why the bacterial
makeup of your gut would have an influence on your mental and emotional
health relates to the fact that your gut actually works much like a
second brain.
Your central nervous system (composed of your
brain and spinal cord) and your enteric nervous system (the intrinsic
nervous system of your gastrointestinal tract) are created from
identical tissue during fetal development. One part turns into your
central nervous system while the other develops into your enteric
nervous system. These two systems are connected via the vagus nerve, the
tenth cranial nerve that runs from your brain stem down to your
abdomen.
It is now well established that the vagus nerve is the
primary route your gut bacteria use to transmit information to your
brain. Even more interesting, serotonin is produced in your gut as well
as your brain, by specific bacteria. In fact, the greatest concentration
of serotonin is found in your intestines, not your brain.
It's not so surprising then that researchers keep finding positive
correlations between gut health and improved mental health. Most
recently, researchers found that fermented foods and drinks helped curb social anxiety disorder in young adults. The study,12,13 published in Psychiatry Research, involved 710 psychology students at the College of William and Mary.
The participants filled out questionnaires rating their level of worry
and anxiety, and documented their fermented food consumption over the
past 30 days. Other factors such as healthy diet and exercise were also
addressed. Among those who rated themselves as having a high degree of
neurotic feelings, eating more fermented foods was linked to fewer
symptoms of social anxiety. Meaning, the relationship between fermented
foods and decreased social anxiety was strongest among those who tended
to be more neurotic.
Key Factors to Overcoming Anxiety and/or Depression Without Drugs
It's important to realize that your diet and general lifestyle are
foundational factors that must be optimized if you want to resolve
mental health problems such as depression or anxiety, because your body
and mind are so closely interrelated. Compelling research demonstrates
just how interconnected your mental health is with your gastrointestinal
health for example. While many think of their brain as the organ in
charge of their mental health, your gut may actually play a far
more significant role. The drug treatments available today for
depression are no better than they were 50 years ago.
Clearly, we need a new approach, and your diet is an obvious place to
start. Research tells us that the composition of your gut flora not only
affects your physical health, but also has a significant impact on your
brain function and mental state, and your gut microbiome can be quickly
impacted by dietary changes—for better or worse. Research has also
revealed there are a number of other safe effective ways to address
depression and anxiety that do not involve hazardous drugs. So,
if you suffer from an anxiety- or depression-related disorder, please
consider addressing the following diet and lifestyle factors before you
resort to drugs:
| Dramatically decrease your consumption of processed foods, sugar (particularly fructose), grains, and GMOs |
High sugar and starchy carbohydrates lead to excessive insulin
release, which can result in falling blood sugar levels, or
hypoglycemia. In turn, hypoglycemia causes your brain to secrete
glutamate in levels that can cause agitation, depression, anger,
anxiety, and panic attacks. Additionally, sugar fans the flames of
inflammation in your body.
In addition to being high in sugar and grains, processed foods also
contain a variety of additives that can affect your brain function and
mental state, especially MSG, and artificial sweeteners such as
aspartame. There's a great book on this subject, The Sugar Blues, written by William Dufty more than 30 years ago, that delves into the topic of sugar and mental health in great detail.
Recent research also shows that glyphosate,
which is used in large quantities on genetically engineered (GE) crops
like corn, soy, and sugar beets, limits your body's ability to detoxify
foreign chemical compounds. As a result, the damaging effects of those
toxins are magnified, potentially resulting in a wide variety of
diseases, including brain disorders that have both psychological and
behavioral effects. |
| Increase consumption of traditionally fermented and cultured foods |
Reducing gut inflammation is imperative when addressing mental health issues,14
so optimizing your gut flora is a critical piece. To promote healthy
gut flora, increase your consumption of probiotic foods, such as
fermented vegetables, kimchee, natto, kefir, and others. |
| Get adequate vitamin B12 |
Vitamin B12 deficiency can contribute to depression and affects one in four people. |
| Optimize your vitamin D levels |
Vitamin D is very important for your mood. In one study, people with
the lowest levels of vitamin D were found to be 11 times more prone to
depression than those who had normal levels.15
Remember, SAD (Seasonal Affective Disorder) is a type of depression
that we know is related to sunshine deficiency, so it would make sense
that the perfect way to optimize your vitamin D is through sun exposure
or a tanning bed. If neither are available, an oral vitamin D3
supplement is highly advisable. Just remember to also increase your vitamin K2 when taking oral vitamin D. |
| Get plenty of animal-based omega-3 fats |
Your brain is 60 percent fat, and DHA, an animal-based omega-3 fat, along with EPA, is crucial for good brain function and mental health.16 Research has shown a 20 percent reduction in anxiety among medical students taking omega-3s.17
Unfortunately, most people don't get enough from diet alone, so make sure you take a high-quality omega-3 fat, such as krill oil.
Dr. Stoll, a Harvard psychiatrist, was one of the early leaders in
compiling the evidence supporting the use of animal based omega-3 fats
for the treatment of depression. He wrote an excellent book that details
his experience in this area called The Omega-3 Connection. |
| Evaluate your salt intake |
Sodium deficiency
actually creates symptoms that are very much like those of depression.
Make sure you do NOT use processed salt (regular table salt), however.
You'll want to use an all natural, unprocessed salt like Himalayan salt,
which contains more than 80 different micronutrients. |
| Get adequate daily exercise |
Exercise is one of the most effective strategies for preventing and
overcoming depression. Studies have shown there is a strong correlation
between improved mood and aerobic capacity. So there's a growing
acceptance that the mind-body connection is very real, and that
maintaining good physical health can significantly lower your risk of
developing depression in the first place.
Exercising
creates new GABA-producing neurons that help induce a natural state of
calm. It also boosts your levels of serotonin, dopamine, and
norepinephrine, which help buffer the effects of stress. |
| Get enough sleep |
You can have the best diet and exercise program possible but if you
aren't sleeping well you can easily become depressed. Sleep and
depression are so intimately linked that a sleep disorder is actually
part of the definition of the symptom complex that gives the label
depression. |
Tapping Your Anxiety Away
Energy psychology techniques, such as the Emotional Freedom Technique (EFT),
can also be very effective for reducing anxiety by correcting the
bioelectrical short-circuiting that causes your body's reactions—without
adverse effects. You can think of EFT as a tool for "reprogramming"
your circuitry, and it works on both realand imagined stressors.
EFT is a form of psychological acupressure, based on the same energy
meridians used in traditional acupuncture for more than 5,000 years to
treat physical and emotional ailments, but without the invasiveness of
needles. Following a 2012 review in the American Psychological
Association's journal Review of General Psychology, EFT is moving closer to meeting the criteria for an "evidence-based treatment."
Recent research has shown that EFT significantly increases positive
emotions, such as hope and enjoyment, and decreases negative emotional
states, including anxiety. EFT is particularly powerful for treating
stress and anxiety because it specifically targets your amygdala and
hippocampus, which are the parts of your brain that help you decide
whether or not something is a threat.18,19
If you recall NIMH's explanation about how your amygdala and
hippocampus are involved in anxiety disorders, you can see why tapping
is such a powerful tool. EFT has also been shown to lower cortisol
levels.20
| Although you can learn the basics of EFT on your own, if you or your
child has a serious anxiety disorder, I highly recommend that you
consult a qualified EFT practitioner. For serious or complex issue you
need a qualified health care professional that is trained in EFT21
to help guide you through the process, as it typically takes years of
training to develop the skill to tap on and relieve deep-seated,
significant issues.
|
There are situations where SSRIs may be warranted, but on the whole,
these mind- and body-numbing drugs are grossly overused. I'd be willing
to bet a majority of people taking them are not appropriate candidates,
and would fare much better were they to address the basic, core issues
relating to their general lifestyle and health. This includes proper
diet, sleep, exercise, and employing effective tools for stress relief.
Exposure
to the outdoors, such as walking barefoot through a grassy field and
getting appropriate amounts of sun exposure, also should not be
underestimated. If you're suffering from emotional or physical pain, I
encourage you to peruse my inventory of tens of thousands of articles,
which address these issues and offer a multitude of safe and effective
alternatives.
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