Why Treat Cancer with Bicarbonate? Baking Soda Rescues Circadian Oscillation
Published on April 19, 2019
In terms of importance, appropriate bicarbonate levels are just as
crucial as hydration, proper breathing (getting enough oxygen) staying
warm, maintaining healthy pH (high oxygen status) and optimal
nutrition. What we learn here changes the face of modern oncology
because it is now clear,
after the most recent research presented below, that bicarbonates should be included in all cancer patients protocols.
Ten years ago I wrote Sodium Bicarbonate – Rich Man’s Poor Man’s Treatment For Cancer. Since then, many researchers have sustained the assertion that it would be deplorable to leave this most basic substance out of anyone’s cancer treatment, even if one is using toxic chemotherapy and radiation.
I am not suggesting that anyone should follow Dr. Tullio Simoncini’s bicarbonate treatments administered intravenously. There is little flexibility in the blood for pH changes. Simoncini got into serious trouble for over alkalizing the blood of a patient, a condition that easily ends in death. Using oral and transdermal administration is preferable not only because of safety issues but also because one can get bicarbonate to all the cells in the body, which is impossible if one adds bicarbonate directly into the blood.
Simple baking soda is the ideal medicine for mitigating radiation exposure. It helps clear the kidneys of uranium toxicity. It certainly has been used when chemotherapy is administered and during cardiac arrest. It is also the treatment of choice for fungus infections. It addresses CO2 deficiencies. It helps in efforts to detoxify the body of the thousands of chemicals infecting us. It is an excellent antiviral pulling the rug out from under the little critters that are sensitive to pH changes. Most viruses are pH sensitive.
Now we have more reason than ever to focus on bicarbonate therapy for cancer. A new Ludwig Cancer Research study said, “If you want to clean cancer’s clock—that is, defeat it decisively—you may want to really clean it—that is, restore it to proper working order. Only
cancer cells that remain active, in sympathy with the tick-tock of
their internal circadian mechanisms, remain susceptible to cancer
therapies. So, how might these circadian mechanisms be kept in motion?
Sodium bicarbonate now promises to awaken cancer cells that have gone
to sleep deep inside tumors, where oxygen deprivation and acidic conditions go hand in hand. By buffering against acidification, sodium bicarbonate rescues circadian oscillation.”
The study, presented May 31 2018, in the journal Cell, in an article entitled ‘Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR’. “Unexpectedly, we uncover a profound disruption of the circadian clock and diurnal transcriptome when hypoxic cells are permitted to acidify to recapitulate the tumor micro-environment,” the article states. “Buffering against acidification or inhibiting lactic acid production fully rescues circadian oscillation.”
The study’s authors, led by Chi Van Dang, M.D., Ph.D., scientific director of the Ludwig Institute for Cancer Research, conclude that acid produced during the cellular metabolic response to hypoxia suppresses the circadian clock through diminished translation of clock constituents. Dr. Dang, who is also a professor in the Molecular and Cellular Oncogenesis Program at The Wistar Institute said, “But if you add baking soda to the drinking water given to those mice, the entire tumor lights up with mTOR activity. The prediction would be that by reawakening these cells, you could make the tumor far more sensitive to therapy.”
“We started out with a question about oxygen starvation and the circadian clock, and we ended up discovering a new mechanism by which acidic conditions in tissues shut off a lot of things—including the cell’s molecular clock,” muses Dang.
The finding that something as simple as baking soda could reverse this effect and render quiescent cancer cells susceptible to cancer therapies excites Dang. “The concept is so easy,” he says. “It’s not some $100,000 per year drug. It’s literally just baking soda.” Using MRI, medical scientists have seen how much of tagged bicarbonate is converted into carbon dioxide within tumors. In more acidic tumors, more bicarbonate is converted into carbon dioxide.
“Studies conducted at the University of Bari in Italy clearly demonstrated that a hallmark of all tumors, regardless of their origin or background, is their acidic environment. In fact, tumor progression increased with an acidic pH and hypoxia, or a low oxygen level,” writes Dr. Veronique Desaulniers. The perturbation in pH dynamics rises very early in carcinogenesis and is one of the most common patho-physiological hallmarks of tumors.”
“The results of a study suggest that tumor cells do, indeed, perform niche engineering by creating an acidic environment that is non-toxic to the malignant cells but, through its negative effects on normal cells and tissue, promotes local invasion.”
Tumor invasion did not occur into regions with normal or near-normal pH. Immuno-histochemical analyses revealed that cells in the invasive edges expressed the glucose transporter GLUT-1 and the sodium-hydrogen exchanger NHE-1, both of which were associated with peritumoral acidosis. In support of the functional importance of our findings, oral administration of sodium bicarbonate was sufficient to increase peritumoral pH and inhibit tumor growth and local invasion in a preclinical model, supporting the acid-mediated invasion hypothesis.
Increased systemic concentrations of pH buffers leads to reduced intratumoral and peritumoral acidosis. Oral NaHCO3 selectively increased the pH of tumors and reduced the formation of spontaneous metastases in mouse models of metastatic breast cancer. NaHCO3 therapy also reduced the rate of lymph node involvement and significantly reduced the formation of hepatic metastases. Acid pH was shown to increase the release of active cathepsin B, an important matrix remodeling protease.
“I believe that, conservatively, 15 to 20% of all cancer is caused by infections; however, the number could be larger—maybe double,” said Dr. Andrew Dannenberg, director of the Cancer Center at New York-Presbyterian Hospital/Weill Cornell Medical Center. Dr. Dannenberg made the remarks in a speech in December 2007 at the annual international conference of the American Association for Cancer Research so it is another reason to treat cancer with a bicarbonate, which has strong anti-infection effects.
Below is the product that I use daily to get my sodium and potassium bicarbonate. In the next chapter, which merges the use of bicarbonates with fasting, we will introduce magnesium bicarbonate, which one can add to all one’s water. Magnesium bicarbonate is the strongest form of bicarbonate, has no salt though it does not compare in terms of cost with sodium or potassium bicarbonate.
pH ADJUST may
be used to increase salivary and urinary pH; counteract overly acidic
conditions in the digestive tract, blood, and kidneys; and to
supplement the body with the minerals potassium, magnesium, and sodium.
The product contains (in powder form) potassium bicarbonate, magnesium
carbonate, potassium glycinate, and sodium bicarbonate. Each serving
(about ¼ tsp) contains about 300 mg of bicarbonate, 260 mg of
carbonate, 142 mg of potassium, 105 mg of magnesium, 48 mg of sodium,
and 100 mg of glycine.
Potassium is excellent for heart health and in potassium sufficient people, it reduces risk of strokes. Potassium also helps maintain healthy digestive and muscular function.
after the most recent research presented below, that bicarbonates should be included in all cancer patients protocols.
Ten years ago I wrote Sodium Bicarbonate – Rich Man’s Poor Man’s Treatment For Cancer. Since then, many researchers have sustained the assertion that it would be deplorable to leave this most basic substance out of anyone’s cancer treatment, even if one is using toxic chemotherapy and radiation.
I am not suggesting that anyone should follow Dr. Tullio Simoncini’s bicarbonate treatments administered intravenously. There is little flexibility in the blood for pH changes. Simoncini got into serious trouble for over alkalizing the blood of a patient, a condition that easily ends in death. Using oral and transdermal administration is preferable not only because of safety issues but also because one can get bicarbonate to all the cells in the body, which is impossible if one adds bicarbonate directly into the blood.
Simple baking soda is the ideal medicine for mitigating radiation exposure. It helps clear the kidneys of uranium toxicity. It certainly has been used when chemotherapy is administered and during cardiac arrest. It is also the treatment of choice for fungus infections. It addresses CO2 deficiencies. It helps in efforts to detoxify the body of the thousands of chemicals infecting us. It is an excellent antiviral pulling the rug out from under the little critters that are sensitive to pH changes. Most viruses are pH sensitive.
Breakthrough Bicarbonate Cancer Research
You can think of the circadian cycle as a sort
of internal clock of your body that regulates many different
mechanisms. The cycle starts over about every 24 hours (hence the term
“circadian”, coming from Latin circa “about” and dies “day”), and among
its many functions, it tells cells when they’re supposed to produce
and consume nutrients. Healthy cells are normally allowed to do so for
about 12 hours a day, in order to prevent them from being overwhelmed by
a flood of excessive nutrients.”
In order to keep dividing indefinitely, cancer
cells cannot afford the periodic fasting imposed by the circadian
rhythm; before they can divide, they need to grow, and in order to
grow, they need nutrients. Therefore, furiously paced division requires
furiously paced nutrient intake. Hence, all cancers evolve strategies
to get around the circadian limitation.”
Acidification, the Ludwig researchers report, essentially disengages
some of the elements that keep the cell’s circadian clock ticking.
This acid-mediated effect, the researchers assert, can be reversed by
sodium bicarbonate. When they gave tumor-xenografted mice water that
had been supplemented with sodium bicarbonate, the acidity of hypoxic
patches in the tumors was neutralized. The study, presented May 31 2018, in the journal Cell, in an article entitled ‘Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR’. “Unexpectedly, we uncover a profound disruption of the circadian clock and diurnal transcriptome when hypoxic cells are permitted to acidify to recapitulate the tumor micro-environment,” the article states. “Buffering against acidification or inhibiting lactic acid production fully rescues circadian oscillation.”
The study’s authors, led by Chi Van Dang, M.D., Ph.D., scientific director of the Ludwig Institute for Cancer Research, conclude that acid produced during the cellular metabolic response to hypoxia suppresses the circadian clock through diminished translation of clock constituents. Dr. Dang, who is also a professor in the Molecular and Cellular Oncogenesis Program at The Wistar Institute said, “But if you add baking soda to the drinking water given to those mice, the entire tumor lights up with mTOR activity. The prediction would be that by reawakening these cells, you could make the tumor far more sensitive to therapy.”
“We started out with a question about oxygen starvation and the circadian clock, and we ended up discovering a new mechanism by which acidic conditions in tissues shut off a lot of things—including the cell’s molecular clock,” muses Dang.
The finding that something as simple as baking soda could reverse this effect and render quiescent cancer cells susceptible to cancer therapies excites Dang. “The concept is so easy,” he says. “It’s not some $100,000 per year drug. It’s literally just baking soda.” Using MRI, medical scientists have seen how much of tagged bicarbonate is converted into carbon dioxide within tumors. In more acidic tumors, more bicarbonate is converted into carbon dioxide.
Cancer and pH
Virtually every cancer patient will benefit from the use of sodium bicarbonate because
it treats the low oxygen acid conditions universally found in cancer
patients. Sodium bicarbonate shrinks tumors. (Bicarbonate inhibits spontaneous metastases (Robey 2009). ‘Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases’ according to medical scientists. NaHCO3
therapy significantly reduced the formation of hepatic metastases
following intrasplenic injection, suggesting that it did inhibit
extravasation and colonization. “Studies conducted at the University of Bari in Italy clearly demonstrated that a hallmark of all tumors, regardless of their origin or background, is their acidic environment. In fact, tumor progression increased with an acidic pH and hypoxia, or a low oxygen level,” writes Dr. Veronique Desaulniers. The perturbation in pH dynamics rises very early in carcinogenesis and is one of the most common patho-physiological hallmarks of tumors.”
“The results of a study suggest that tumor cells do, indeed, perform niche engineering by creating an acidic environment that is non-toxic to the malignant cells but, through its negative effects on normal cells and tissue, promotes local invasion.”
Tumor invasion did not occur into regions with normal or near-normal pH. Immuno-histochemical analyses revealed that cells in the invasive edges expressed the glucose transporter GLUT-1 and the sodium-hydrogen exchanger NHE-1, both of which were associated with peritumoral acidosis. In support of the functional importance of our findings, oral administration of sodium bicarbonate was sufficient to increase peritumoral pH and inhibit tumor growth and local invasion in a preclinical model, supporting the acid-mediated invasion hypothesis.
Increased systemic concentrations of pH buffers leads to reduced intratumoral and peritumoral acidosis. Oral NaHCO3 selectively increased the pH of tumors and reduced the formation of spontaneous metastases in mouse models of metastatic breast cancer. NaHCO3 therapy also reduced the rate of lymph node involvement and significantly reduced the formation of hepatic metastases. Acid pH was shown to increase the release of active cathepsin B, an important matrix remodeling protease.
Cancer, Infections and Baking Soda
Oncologist Dr. Tullio Simoncini was persecuted for his use of sodium
bicarbonate for cancer patients because he laid attention to the
relationship between cancer and fungus. It needs to be remembered when
connecting cancer with fungus that Cancer—always
believed to be caused by genetic cell mutations—can in reality be
caused by infections from viruses, bacteria, and fungi. “I believe that, conservatively, 15 to 20% of all cancer is caused by infections; however, the number could be larger—maybe double,” said Dr. Andrew Dannenberg, director of the Cancer Center at New York-Presbyterian Hospital/Weill Cornell Medical Center. Dr. Dannenberg made the remarks in a speech in December 2007 at the annual international conference of the American Association for Cancer Research so it is another reason to treat cancer with a bicarbonate, which has strong anti-infection effects.
Conclusion
Greater knowledge of the mechanisms that contribute to the survival
of tumor cells is key to vanquishing them. Shutting down the circadian
oscillation is one principle strategy that cancer cells employ to thrive
and sodium bicarbonate fully rescues circadian oscillation. Thus it is
time for mainstream oncologists to wake up to what medical science has
to say about bicarbonates. There is just too much benefit and
practically zero downside to bicarbonates. Bicarbonate has long been
used in ICU, emergency departments and in ambulances. There is no reason
it should not be employed for all cancer patients. Below is the product that I use daily to get my sodium and potassium bicarbonate. In the next chapter, which merges the use of bicarbonates with fasting, we will introduce magnesium bicarbonate, which one can add to all one’s water. Magnesium bicarbonate is the strongest form of bicarbonate, has no salt though it does not compare in terms of cost with sodium or potassium bicarbonate.
Potassium is excellent for heart health and in potassium sufficient people, it reduces risk of strokes. Potassium also helps maintain healthy digestive and muscular function.
See References ▼
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