Low Frequency Electromagnetic
Fields Cause DNA Damage
From Klaus Rudolph
Citizens' Initiative Omega
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| Intermittent Extremely Low Frequency Electromagnetic Fields
Cause DNA Damage In A Dose-Dependent Way|
By Ivancsits S, Diem E, Jahn O, Rudiger HW. Division of Occupational Medicine, University Hospital/AKH, Waehringer Guertel 18-20, 1090, Vienna, Austria.
OBJECTIVES. Epidemiological studies have reported an association between exposure to extremely low frequency electromagnetic fields (ELF-EMFs) and increased risk of cancerous diseases, albeit without dose-effect relationships. The validity of such findings can be corroborated only by demonstration of dose-dependent DNA-damaging effects of ELF-EMFs in cells of human origin in vitro.
METHODS. Cultured human diploid fibroblasts were exposed to intermittent ELF electromagnetic fields. DNA damage was determined by alkaline and neutral comet assay.
RESULTS. ELF-EMF exposure (50 Hz, sinusoidal, 1-24 h, 20-1,000 MicroTesla, 5 min on/10 min off) induced dose-dependent and time-dependent DNA single-strand and double-strand breaks. Effects occurred at a magnetic flux density as low as 35 MicroTesla being well below proposed International Commission of Non-Ionising Radiation Protection (ICNIRP) guidelines. After termination of exposure the induced comet tail factors returned to normal within 9 h.
CONCLUSION. The induced DNA damage is not based on thermal effects and arouses concern about environmental threshold limit values for ELF exposure.
Int Arch Occup Environ Health. 2003 Jun 12 in print http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&lis _uids=12802592&dopt=Abstract
Evaluation Of Rat Thyroid Gland Morphophysiological Status After Three Months Exposure To 50 Hz Electromagnetic Field
By Rajkovic V, Matavulj M, Gledic D, Lazetic B.
Department of Histology and Embryology, Institute of Biology, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovica 2, 21000, Novi Sad, Yugoslavia
Objective of our study was to use morphophysiological criteria in order to determine the sensitivity of male rat thyroid gland to an extremely low frequency electromagnetic field (ELF-EMF) influence and the ability of the gland to repair after period of exposure.
Animals were exposed to 50Hz, 50-500 MicroTesla ELF-EMF for 3 months when a part of them (group I) were sacrificed, while the rest of animals were subjected to recovery evaluation of the gland and sacrificed after 1 (group II), 2 (group III) and 3 (group IV) weeks. Histological and stereological analyses were performed on paraffin and semifine thyroid gland sections. Serum T3 and T4 were also determined.
Histological and stereological analyses showed that the volume density of follicular epithelium and thyroid activation index decreased, while the volume density of colloid and capillary network increased in group I, II and III. The values of all these parameters in group IV were similar to corresponding controls. Serum T3 and T4 concentrations were significantly lower in all exposed animals, except in group I.
Results of this study demonstrate that after significant morphophysiological changes caused by ELF-EMF exposure thyroid gland recovered morphologically, but not physiologically, during the investigated repair period.
Tissue Cell. 2003 Jun;35(3):223-231.
Childhood Leukemia: Electric And Magnetic Fields As Possible Risk Factors
By Brain JD, Kavet R, McCormick DL, Poole C, Silverman LB, Smith TJ, Valberg PA, Van Etten RA, Weaver JC.
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA.
Numerous epidemiologic studies have reported associations between measures of power-line electric or magnetic fields (EMFs) and childhood leukemia.
The basis for such associations remains unexplained. In children, acute lymphoblastic leukemia represents approximately three-quarters of all U.S. leukemia types.
Some risk factors for childhood leukemia have been established, and others are suspected. Pathogenesis, as investigated in animal models, is consistent with the multistep model of acute leukemia development. Studies of carcinogenicity in animals, however, are overwhelmingly negative and do not support the hypothesis that EMF exposure is a significant risk factor for hematopoietic neoplasia.
We may fail to observe effects from EMFs because, from a mechanistic perspective, the effects of EMFs on biology are very weak. Cells and organs function despite many sources of chemical "noise" (e.g., stochastic, temperature, concentration, mechanical, and electrical noise), which exceed the induced EMF "signal" by a large factor.
However, the inability to detect EMF effects in bioassay systems may be caused by the choice made for "EMF exposure." "Contact currents" or "contact voltages" have been proposed as a novel exposure metric, because their magnitude is related to measured power-line magnetic fields. A contact current occurs when a person touches two conductive surfaces at different voltages. Modeled analyses support contact currents as a plausible metric because of correlations with residential magnetic fields and opportunity for exposure.
The possible role of contact currents as an explanatory variable in the reported associations between EMFs and childhood leukemia will need to be clarified by further measurements, biophysical analyses, bioassay studies, and epidemiology.
Environ Health Perspect. 2003 Jun;111(7):962-970.
Informant: Reinhard Rueckemann
Please look at this text on the mechanisms of the EMF (too many scientists 'officials' say still " there are no explanations "!) http://www.csif-cem.org/hspen.html
Here is the abstract :
EMF and Stress proteins (Hsp) or Heat shock proteins Richard GAUTIER (Dr en pharmacie), Roger SANTINI (Dr es sciences) http://www.csif-cem.org le 17/06/2003
Abstract: Increase of synthesis of Hsp by the electromagnetic fields (EMF) generally or by the radio frequencies of the mobile telephony in particular was widely demonstrated. By studying works relative to the cellular biochemistry we realizes that these mechanisms are known (activation of the way of the MAP Kinase and Hsp, deregulation of the protein synthesis, apoptose pathway) and consequences in sanitary terms established, whether it is in term of resistance in anti-cancerous treatments, of confusions of the intellectual activity, infringement of the BHE, the deficit of the immunity, the development of cancer.
Informant: Dr Richard Gautier