Dr. Bradstreet, Nagalase, and the Viral Issue in Autism
Although my daughter is not a patient of Dr. Jeff Bradstreet I've always had an enormous amount of respect for the good doctor. I'll usually go on his website once or twice a month to find out what has most recently attracted his interest. Often it seems we're looking at similar questions; which either means great minds think alike, or we suffer from some of the same delusions.
I was intrigued by his October 11, 2011 entry, "An Update on Viral Issue in Autism" since it dovetailed with some of my own recent investigations.
In the past months Dr. Bradstreet has become interested in nagalese, which he describes as an enzyme "produced by cancer cells and viruses." He thinks it unlikely that children with autism have undiagnosed cancers, and thus suspicion falls on a viral etiology. Dr. Bradstreet writes, "Viruses make the nagalese enzyme as part of their attachment proteins. It serves to get the virus into the cell and also decreases the body's immune reaction to the virus-thereby increasing the odds of viral survival."
Further on Dr. Bradstreet writes, "It is reasonable and likely that the nature of the immune dysfunction and the frequently observed autoimmune problems in autism are mediated by persistent, unresolved viral infections." He claims to have tested approximately 400 children with autism for the viral marker, nagalese, and found that nearly 80% have significantly elevated levels. He hopes to publish soon on this study and believes this information "is one of the most important developments in the clinical treatment of children on the spectrum that I have experienced in the last 15 years."
Dr. Bradstreet's article got my attention because of my daughter's
own nagalese testing. I had her tested back in May (when she'd endured
three hospitalizations due to uncontrolled seizures) and her reading was
3.3 (reference range 0.35-0.95). In desparation we tried the ketogenic
diet (high fats and low carbs), and although there have been some rough
patches since May we have avoided further hospitalizations.
And her stools normalized.
Yes, I know all of you realize how important that is. We're talking months and months of good stools. Seizures down at least 80%. So of course, your friendly neighborhood science teacher was interested in what her nagalese levels might be, so we did a retest in late September. This time her reading was 1.7. It was about a 50% drop, and while it's still abnormal, it is progress. It makes me wonder if a low-carb diet starves viruses of an energy source.
There are critics of nagalese testing. Dr. Enlander, a specialist in chronic fatigue syndrome/ME, another disease which may be viral in origin, doesn't believe the tests are sensitive enough to be of any value. And he may be right.
Dr. Bradstreet also discusses a substance called GcMAF, which I don't have enough information about to make an informed judgment, and that after viral clearance, the possibility of using neuronal stem cells which can cross the blood-brain barrier. I really can't comment on the advisability of either suggestion.
But if you are like me, still looking for that clue which might help your child join the ranks of the recovered, you might investigate nagalese.
Kent Heceknlively is a Contributing Editor to Age of Autism
And her stools normalized.
Yes, I know all of you realize how important that is. We're talking months and months of good stools. Seizures down at least 80%. So of course, your friendly neighborhood science teacher was interested in what her nagalese levels might be, so we did a retest in late September. This time her reading was 1.7. It was about a 50% drop, and while it's still abnormal, it is progress. It makes me wonder if a low-carb diet starves viruses of an energy source.
There are critics of nagalese testing. Dr. Enlander, a specialist in chronic fatigue syndrome/ME, another disease which may be viral in origin, doesn't believe the tests are sensitive enough to be of any value. And he may be right.
Dr. Bradstreet also discusses a substance called GcMAF, which I don't have enough information about to make an informed judgment, and that after viral clearance, the possibility of using neuronal stem cells which can cross the blood-brain barrier. I really can't comment on the advisability of either suggestion.
But if you are like me, still looking for that clue which might help your child join the ranks of the recovered, you might investigate nagalese.
Kent Heceknlively is a Contributing Editor to Age of Autism
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I cast my mind back to the great Pharma idol (he who should be worshipped ) of Pharma ,caught on camera talking about Merck vaccine scientist Dr. Maurice Hilleman admitted presence of SV40, AIDS and cancer viruses in vaccines…
“NaturalNews) One of the most prominent vaccine scientists in the history of the vaccine industry -- a Merck scientist -- made a recording where he openly admits that vaccines given to Americans were contaminated with leukemia and cancer viruses. In response, his colleagues (who are also recorded here) break out into laughter and seem to think it's hilarious. They then suggest that because these vaccines are first tested in Russia, they will help the U.S. win the Olympics because the Russian athletes will all be "loaded down with tumors." (Thus, they knew these vaccines caused cancer in humans.)”
Transcript
http://www.naturalnews.com/033584_dr_maurice_hilleman_sv40.html#
Video
https://www.youtube.com/results?search_query=maurice+hillieman+
Soo you see they f... knew what they were doing,MAURICE KNEW...Even the pharma paid puppet sock publications Pubmed et-al admit to nagalese …the telling point is ,you don’t find many studies, as the writer below points out some articles are written about then a sudden death of information.
http://www.ncbi.nlm.nih.gov/pubmed/16545013
Just think if everyone went to alternative practioners instead of allopathic the trillions of dollars pharma would loose and everyone would be healthier for it, the costs worldwide for health care would plummet tomorrow, everyone would be able to get healthcare for what ever rare, occurrence came along.
Dr Bradstreet et-al were starting to make a miniscule, impact on that road to recovery for everyone. I for one know that it wasn’t easy getting an appointment with Dr Bradstreet and the carpark at his clinic and other alternative practioners, in America are usually full to capacity ..says it all don’t you think?The comments below say it far better than I can RIP Dr Bradstreet, one extra star in the sky now.
MMR RIP
MMR RIP
http://www.la-press.com/initial-observations-of-elevated-alpha-n-acetylgalactosaminidase-activ-article-a3450-abstract
We are pleased to supply both Dr Bradstreet & Dr Nicola Antonucci with GcMAF who have treated over 1500 autistic children to date and are actively seeking other researchers to further the study already underway.
Please email me at info@gcmaf.eu - thank you.
With very best regards
Trevor
Has anyone tried MAF 314? Not sure if we should use Gcmaf or maf314 on our 5yr old, non verbal child.
Di
The simple fact is that a nagalase test will basically tell you if there is some kind of virus in your body. A high reading will indicate that there is and that it has seriously affected your immune system and your system isnt working proprly, so the virus can quite happily live inside you.
So for a very simple 50 -65 euros you can have a definite answer. If your levels are normal then at least you know the autism isnt caused by some kind of virus and that autism is really symptoms of having this virus living inside you.
If the test returns high levels then it is incredibly significant and there is a very real chance that the autism or severity of the autism is being caused by a virus. there is a very definite and single path of treatment to take.
I urge everyone with autistic people in their family (especially severe autism) to get the test done because you can learn a huge amount about what might or might not be the cause of autism for just 50-65 euros. It's better to learn something and open or close a path than to never know and just live with it your entire life.
If a nagalase test returns high levels then i suggest you then look to get a Vitamin D receptor gene type test. Right now it seems that 2 types of genes are high responders, but the rarest type of gene is a non responder. Tat is where we are just now, and the next step being worked on now is a way to bypass the non responsive gene or try to figure out some way of being able to treat everyone regardless of their gene type. But a Vit D recep test is another cheap way for you to know if the next step of treatment is likely to work, if the person has the rare gene type then it would seem right now that treatment wouldnt be effective.
if anyone with severe autism in their lives wold like any more info or help or support then please feel free to contact me angelesshc@gmail.com
i have autism and am going down this path myself, for the cost of a simple couple of test i will learn a huge amount about what is happening inside me, so a normal or high test result can be seen as a positive thing.
Fascinating information. Where did everybody get their Nagalase tests?
I want to use such a test as a screening test for the many causes of
high levels in serum. The one I know of costs about $65 and must be
ordered by a doctor.
The other source of Nagalase is pregnancy, I presume only after mother
and fetus share blood. Since cancer is created by a series of
aneuploid accidents after an initial wrong number of chromosomes, I
suspect that it's the fetal source gene that cancers use. I understand
that if you're HIV+, and gp120 is present, that serves as Nagalase on
its own.
I suspect that anything that emits Nagalase is protecting itself from
activated macrophages on the rampage looking for cells to consume with
active virus or the wrong chromosome complement such as a cancer cell
or a fetal cell or whatever makes gp120. I also suspect that cancers
that don't make Nagalase get eaten before they get big enough to get
noticed.
Professor Marco Ruggiero has created a probiotic yogurt, MAF 3 14,
which apparently makes people with a variety of ailments feel better
and have improved CD4 counts within weeks of starting consumption. He
had heard that milk contains some vitamin D binding protein, known as
either VDBP or Gc, and after 314 experiments found tasty yogurt
bacteria that converted some of the VDBP into macrophage activating
factor, MAF.
Ruggiero's recent report on MAF 314 at a conference in Italy is listed
among my many links. I have many more related links if anyone cares to
help annotate them to make the lists more useful. The only way I know
to get it is to take a $3500 course in maintaining properly balanced
yogurt and get 6 months worth of live yogurt starter material. I am
hoping to see MAF 314 spread widely by what I'm starting to call the
yogurt underground.
thanks.
I used this lab in New Jersey. http://www.europeanlaboratory.nl/ Cost was $65.00.
All the best,
Kent.
Maurine
Freitag, 24. September 2010, 12:30 - 14:30
Immunotherapy of anti-NMDA receptor encephalitis with rituximab – short report on a prospective one year follow-up
H. Schneider, A. Kotzian, U. Reuner, J. Schäfer, A. Vincent (Dresden; Oxford, UK)
Introduction: A new type of treatable encephalitis which predominantly affects young women has recently been described. The disorder is characterized by personality changes, seizures, dyskinesia and dysautonomia. Most patients have autoantibodies against NR1/NR2B subunits of the N-methyl-D-aspartate receptor (NMDAR), and in the majoritiy of patients a tumor, particularly an ovarian teratoma, can be detected.
Case report: We report about a female patient with clinical signs of limbic dysfunction and subacute onset of symptoms suggestive of NMDAR encephalitis. Anti-NMDAR-antibodies were detected in the patient and treatment with steroids and rituximab was initiated. The patient was followed-up for one year and showed complete remission of symptoms within 6 months. No ovarian teratoma or other tumor could be identified. CD19-positive B cells were completely suppressed by rituximab therapy. Serum levels of NMDAR-antibodies did not completely reflect the clinical course of the disease.
Summary: Our report proves the long-lasting clinical effect of B cell specific treatment with rituximab in a tumor-negative patient with NMDAR-encephalitis.
My son was on the Modified Atkins Diet for two and a half years. I just took him off this past summer. I put him on it for seizure, gut and mito issues. It was a dramatic diet and my son is now doing wonderful. Now your article has me curious as to other underlying issues. I'm going to research more. Thank you for your article. I appreciate your curiosity and willingness to inform us all.
Jacey
http://psychcentral.com/news/2011/10/20/potential-link-between-type-2-diabetes-and-autism/30542.html
Plus, I'm sure by now you've seen Dr. Buie and company's paper on carb metabolism issues in autism. By lowering carbohydrates in the diet, you're also radically changing gut flora. (The reason SCD works so well with so many kids.) Interesting that you saw a change in nagalase levels with the keto diet. You do have to wonder if there's any relationship.
Yes, we did the ketogenic diet under our neurologist's care.
I am somewhat familiar with GcMAF, but don't feel I have a good understanding yet of who it might help.
I'm also familiar with rituximab, and am waiting to see how it all shakes out before writing about it.
All the best,
Kent
http://www.eurekalert.org/pub_releases/2011-10/ru-rpc101911.php
From a systems biology standpoint, these seem to be hitting or centering on Hubs and Nodes, the most connected and presumably most important proteins in cells. These tend to be the encoded by the genes mutated in major diseases like cancer.
Our son has been his patient since 2002 and has gone from a pale, non-verbal, self-stemming five-year-old with significant gut issues to an athletic 12-year-old in a classroom with "neuro-typical" children, on the honor roll, and something of a social butterfly.
We give credit to the courage of our son, of course, but his progress would not have been possible without the brilliant, hard work of Jeff Bradstreet. Talk to the families of any of his other patients and you will hear similar tales. It is hard to overstate the creative and positive difference this physician has made in the lives of our children.
Below is a link to a presentation on GcMAF that helps to explain some of the science behind the treatments and the role of nagalese that Dr. Bradstreet is pursuing. The presentation is by Dr. Kevin Bethel, Research Director at the IAT Cancer Clinic in Freeport, Bahamas.
Part 1: http://youtu.be/9o0J8dYfM3Q
Part 2: http://youtu.be/rkD2nni28Xs
Although you and Dr. Bradstreet mention this avenue of inquiry and treatment as a potential breakthrough for children on the spectrum, readers might be interested to know that GcMAF is increasingly seen as a potential breakthrough treatment for cancer and other immune diseases.
The research scientist most often credited with developing this line of inquiry is Dr. Yamamoto. Here is a PubMed entry from July 2008:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2510818/
Other PubMed entries on GcMAF can be found here:
http://www.ncbi.nlm.nih.gov/pmc/?term=gcmaf
I hope that AoA will continue to follow and report on Dr. Bradstreet's trials of GcMAF and the role of nagalese in causing the immune disorders of children on the spectrum.
http://www.pediatrics.ucsd.edu/news/pages/recurrentfeverresearch.aspx
The Ketogenic diet is a rough diet, but it is only two years that you are suppose to stay on it, so good luck!
I am very curious though, if you did it yourself, or did you have professional help?
Jon Poling has his daughter on the 15 carb Atkin's diet and John Hopkins research says it works very well, also John Hopkins said that a glycemic diet of 30 carbs works too, but geeezze to figure out how much you can eat of a slow release cut steel oatmeal - not enough knowledge there.
Yesterday I read this from "Scientist News"
An anti-cancer drug could hold the key to treating chronic fatigue syndrome (CFS). Symptoms of the disease eased in 10 of 15 patients given rituximab, an anti-lymphoma drug.
Rituximab works by destroying white blood cells that make antibodies, called B cells. The results of the trial therefore suggest that these white blood cells might be involved in causing CFS – a disorder also known as myalgic encephalomyelitis (ME), and one that has so far defied explanation
Two words that stand out for my is lymphoma - lymph nodes, and B cells.
In Kawasakis disesase- is messed up with all of this too. There have been two studies released that link periodic fever disorder to Kawasakis. PFAPA (periodic or recurrent fever syndrome).
Which I and many parents have complained about for years. After the kids gets over the intial Kawasakis they have a fever once or twice a month that last about a week, but as the child gets older it slows down more and more (if you don't keep vaccinating). Many parents report that their kids had swollen lymph nodes some where in their bodies too. One of these studies says removing the tonsils "SOME TIMES" stops these recurring fevers.
My son had atypical Kawasakis - I never noticed if his tonisl were swollen though he always had a sore throat, so maybe it was???? However, he had more trouble with recurring fevers than my daughter who had very typical Kawasakis.
For my daughter it was her spleen.
The spleen swelled up to the point that a surgeon was called in - with the intention of removing it. Scary stuff, since a child who has had it's spleen removed seems to be okay, and then near death or dies a few years later.
The spleen and tonsils are large lymphoid organs that serve similar functions to lymph nodes, though the spleen filters blood cells rather than lymph.
It is also in the lymph nodes that the T cells sit around manufacturing lots of carbon copies of immune complexes brought to them by the B cells.
What if a child was lucky enough to have these problem T cells only in its tonsils. It may well make a difference in having them removed.
All this reminds me of amputated arms and legs in the past before there was pencillum, and cleaning wounds techniques.
http://www.pediatrics.ucsd.edu/news/pag ... earch.aspx
http://www.ncbi.nlm.nih.gov/pubmed/21220401